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A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors

We here conducted an image-based chemical screen to evaluate how medically approved drugs, as well as drugs that are currently under development, influence overall translation levels. None of the compounds up-regulated translation, which could be due to the screen being performed in cancer cells gro...

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Detalles Bibliográficos
Autores principales:	Corman, Alba, Kanellis, Dimitris C., Michalska, Patrycja, Häggblad, Maria, Lafarga, Vanesa, Bartek, Jiri, Carreras-Puigvert, Jordi, Fernandez-Capetillo, Oscar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183993/ https://www.ncbi.nlm.nih.gov/pubmed/34033645 http://dx.doi.org/10.1371/journal.pbio.3001263

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