Cargando…

Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla

Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Hartmann, Benedikt, Müller, Max, Seyler, Lisa, Bäuerle, Tobias, Wilferth, Tobias, Avdievitch, Nikolai, Ruhm, Loreen, Henning, Anke, Lesiv, Alexei, Ivashkin, Pavel, Uder, Michael, Nagel, Armin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184010/
https://www.ncbi.nlm.nih.gov/pubmed/34097707
http://dx.doi.org/10.1371/journal.pone.0252935
_version_ 1783704502761684992
author Hartmann, Benedikt
Müller, Max
Seyler, Lisa
Bäuerle, Tobias
Wilferth, Tobias
Avdievitch, Nikolai
Ruhm, Loreen
Henning, Anke
Lesiv, Alexei
Ivashkin, Pavel
Uder, Michael
Nagel, Armin M.
author_facet Hartmann, Benedikt
Müller, Max
Seyler, Lisa
Bäuerle, Tobias
Wilferth, Tobias
Avdievitch, Nikolai
Ruhm, Loreen
Henning, Anke
Lesiv, Alexei
Ivashkin, Pavel
Uder, Michael
Nagel, Armin M.
author_sort Hartmann, Benedikt
collection PubMed
description Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic processing of a deuterium labelled substance. Moreover, DMRS allows the distinction between different deuterated substances. In this work, we performed DMRS of deuterated 3-O-Methylglucose (OMG). OMG is a non-metabolizable glucose analog which is transported similar to D-glucose. DMRS of OMG was performed in phantom and in vivo measurements using a preclinical 7 Tesla MRI system. The chemical shift (3.51 ± 0.1 ppm) and relaxation times were determined. OMG was injected intravenously and spectra were acquired over a period of one hour to monitor the time evolution of the deuterium signal in tumor-bearing rats. The increase and washout of OMG could be observed. Three different exponential functions were compared in terms of how well they describe the OMG washout. A mono-exponential model with offset seems to describe the observed time course best with a time constant of 1910 ± 770 s and an offset of 2.5 ± 1.2 mmol/l (mean ± std, N = 3). Chemical shift imaging could be performed with a voxel size of 7.1 mm x 7.1 mm x 7.9 mm. The feasibility of DMRS with deuterium labelled OMG could be demonstrated. These data might serve as basis for future studies that aim to characterize glucose transport using DMRS.
format Online
Article
Text
id pubmed-8184010
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-81840102021-06-21 Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla Hartmann, Benedikt Müller, Max Seyler, Lisa Bäuerle, Tobias Wilferth, Tobias Avdievitch, Nikolai Ruhm, Loreen Henning, Anke Lesiv, Alexei Ivashkin, Pavel Uder, Michael Nagel, Armin M. PLoS One Research Article Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic processing of a deuterium labelled substance. Moreover, DMRS allows the distinction between different deuterated substances. In this work, we performed DMRS of deuterated 3-O-Methylglucose (OMG). OMG is a non-metabolizable glucose analog which is transported similar to D-glucose. DMRS of OMG was performed in phantom and in vivo measurements using a preclinical 7 Tesla MRI system. The chemical shift (3.51 ± 0.1 ppm) and relaxation times were determined. OMG was injected intravenously and spectra were acquired over a period of one hour to monitor the time evolution of the deuterium signal in tumor-bearing rats. The increase and washout of OMG could be observed. Three different exponential functions were compared in terms of how well they describe the OMG washout. A mono-exponential model with offset seems to describe the observed time course best with a time constant of 1910 ± 770 s and an offset of 2.5 ± 1.2 mmol/l (mean ± std, N = 3). Chemical shift imaging could be performed with a voxel size of 7.1 mm x 7.1 mm x 7.9 mm. The feasibility of DMRS with deuterium labelled OMG could be demonstrated. These data might serve as basis for future studies that aim to characterize glucose transport using DMRS. Public Library of Science 2021-06-07 /pmc/articles/PMC8184010/ /pubmed/34097707 http://dx.doi.org/10.1371/journal.pone.0252935 Text en © 2021 Hartmann et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hartmann, Benedikt
Müller, Max
Seyler, Lisa
Bäuerle, Tobias
Wilferth, Tobias
Avdievitch, Nikolai
Ruhm, Loreen
Henning, Anke
Lesiv, Alexei
Ivashkin, Pavel
Uder, Michael
Nagel, Armin M.
Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla
title Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla
title_full Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla
title_fullStr Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla
title_full_unstemmed Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla
title_short Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla
title_sort feasibility of deuterium magnetic resonance spectroscopy of 3-o-methylglucose at 7 tesla
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184010/
https://www.ncbi.nlm.nih.gov/pubmed/34097707
http://dx.doi.org/10.1371/journal.pone.0252935
work_keys_str_mv AT hartmannbenedikt feasibilityofdeuteriummagneticresonancespectroscopyof3omethylglucoseat7tesla
AT mullermax feasibilityofdeuteriummagneticresonancespectroscopyof3omethylglucoseat7tesla
AT seylerlisa feasibilityofdeuteriummagneticresonancespectroscopyof3omethylglucoseat7tesla
AT bauerletobias feasibilityofdeuteriummagneticresonancespectroscopyof3omethylglucoseat7tesla
AT wilferthtobias feasibilityofdeuteriummagneticresonancespectroscopyof3omethylglucoseat7tesla
AT avdievitchnikolai feasibilityofdeuteriummagneticresonancespectroscopyof3omethylglucoseat7tesla
AT ruhmloreen feasibilityofdeuteriummagneticresonancespectroscopyof3omethylglucoseat7tesla
AT henninganke feasibilityofdeuteriummagneticresonancespectroscopyof3omethylglucoseat7tesla
AT lesivalexei feasibilityofdeuteriummagneticresonancespectroscopyof3omethylglucoseat7tesla
AT ivashkinpavel feasibilityofdeuteriummagneticresonancespectroscopyof3omethylglucoseat7tesla
AT udermichael feasibilityofdeuteriummagneticresonancespectroscopyof3omethylglucoseat7tesla
AT nagelarminm feasibilityofdeuteriummagneticresonancespectroscopyof3omethylglucoseat7tesla