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Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla
Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic pro...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184010/ https://www.ncbi.nlm.nih.gov/pubmed/34097707 http://dx.doi.org/10.1371/journal.pone.0252935 |
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author | Hartmann, Benedikt Müller, Max Seyler, Lisa Bäuerle, Tobias Wilferth, Tobias Avdievitch, Nikolai Ruhm, Loreen Henning, Anke Lesiv, Alexei Ivashkin, Pavel Uder, Michael Nagel, Armin M. |
author_facet | Hartmann, Benedikt Müller, Max Seyler, Lisa Bäuerle, Tobias Wilferth, Tobias Avdievitch, Nikolai Ruhm, Loreen Henning, Anke Lesiv, Alexei Ivashkin, Pavel Uder, Michael Nagel, Armin M. |
author_sort | Hartmann, Benedikt |
collection | PubMed |
description | Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic processing of a deuterium labelled substance. Moreover, DMRS allows the distinction between different deuterated substances. In this work, we performed DMRS of deuterated 3-O-Methylglucose (OMG). OMG is a non-metabolizable glucose analog which is transported similar to D-glucose. DMRS of OMG was performed in phantom and in vivo measurements using a preclinical 7 Tesla MRI system. The chemical shift (3.51 ± 0.1 ppm) and relaxation times were determined. OMG was injected intravenously and spectra were acquired over a period of one hour to monitor the time evolution of the deuterium signal in tumor-bearing rats. The increase and washout of OMG could be observed. Three different exponential functions were compared in terms of how well they describe the OMG washout. A mono-exponential model with offset seems to describe the observed time course best with a time constant of 1910 ± 770 s and an offset of 2.5 ± 1.2 mmol/l (mean ± std, N = 3). Chemical shift imaging could be performed with a voxel size of 7.1 mm x 7.1 mm x 7.9 mm. The feasibility of DMRS with deuterium labelled OMG could be demonstrated. These data might serve as basis for future studies that aim to characterize glucose transport using DMRS. |
format | Online Article Text |
id | pubmed-8184010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-81840102021-06-21 Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla Hartmann, Benedikt Müller, Max Seyler, Lisa Bäuerle, Tobias Wilferth, Tobias Avdievitch, Nikolai Ruhm, Loreen Henning, Anke Lesiv, Alexei Ivashkin, Pavel Uder, Michael Nagel, Armin M. PLoS One Research Article Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic processing of a deuterium labelled substance. Moreover, DMRS allows the distinction between different deuterated substances. In this work, we performed DMRS of deuterated 3-O-Methylglucose (OMG). OMG is a non-metabolizable glucose analog which is transported similar to D-glucose. DMRS of OMG was performed in phantom and in vivo measurements using a preclinical 7 Tesla MRI system. The chemical shift (3.51 ± 0.1 ppm) and relaxation times were determined. OMG was injected intravenously and spectra were acquired over a period of one hour to monitor the time evolution of the deuterium signal in tumor-bearing rats. The increase and washout of OMG could be observed. Three different exponential functions were compared in terms of how well they describe the OMG washout. A mono-exponential model with offset seems to describe the observed time course best with a time constant of 1910 ± 770 s and an offset of 2.5 ± 1.2 mmol/l (mean ± std, N = 3). Chemical shift imaging could be performed with a voxel size of 7.1 mm x 7.1 mm x 7.9 mm. The feasibility of DMRS with deuterium labelled OMG could be demonstrated. These data might serve as basis for future studies that aim to characterize glucose transport using DMRS. Public Library of Science 2021-06-07 /pmc/articles/PMC8184010/ /pubmed/34097707 http://dx.doi.org/10.1371/journal.pone.0252935 Text en © 2021 Hartmann et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Hartmann, Benedikt Müller, Max Seyler, Lisa Bäuerle, Tobias Wilferth, Tobias Avdievitch, Nikolai Ruhm, Loreen Henning, Anke Lesiv, Alexei Ivashkin, Pavel Uder, Michael Nagel, Armin M. Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla |
title | Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla |
title_full | Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla |
title_fullStr | Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla |
title_full_unstemmed | Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla |
title_short | Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla |
title_sort | feasibility of deuterium magnetic resonance spectroscopy of 3-o-methylglucose at 7 tesla |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184010/ https://www.ncbi.nlm.nih.gov/pubmed/34097707 http://dx.doi.org/10.1371/journal.pone.0252935 |
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