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Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials

BACKGROUND: Inhibition of phosphoinositide 3-kinase δ (PI3Kδ) exerts corrective effects on the dysregulated migration characteristics of neutrophils isolated from patients with chronic obstructive pulmonary disease (COPD). OBJECTIVE: To develop novel, induced sputum endpoints to demonstrate changes...

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Detalles Bibliográficos
Autores principales:	Begg, Malcolm, Hamblin, J Nicole, Jarvis, Emily, Bradley, Glyn, Mark, Stephen, Michalovich, David, Lennon, Mark, Wajdner, Hannah E, Amour, Augustin, Wilson, Robert, Saunders, Ken, Tanaka, Rikako, Arai, Saki, Tang, Teresa, Van Holsbeke, Cedric, De Backer, Jan, Vos, Wim, Titlestad, Ingrid L, FitzGerald, J Mark, Killian, Kieran, Bourbeau, Jean, Poirier, Claude, Maltais, François, Cahn, Anthony, Hessel, Edith M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184158/ https://www.ncbi.nlm.nih.gov/pubmed/34113094 http://dx.doi.org/10.2147/COPD.S309303

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