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Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions

Cooperation, paying a cost to benefit others, is widespread. Cooperation can be promoted by pleiotropic ‘win-win’ mutations which directly benefit self (self-serving) and partner (partner-serving). Previously, we showed that partner-serving should be defined as increased benefit supply rate per inta...

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Detalles Bibliográficos
Autores principales: Hart, Samuel Frederick Mock, Chen, Chi-Chun, Shou, Wenying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184212/
https://www.ncbi.nlm.nih.gov/pubmed/33501915
http://dx.doi.org/10.7554/eLife.57838
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author Hart, Samuel Frederick Mock
Chen, Chi-Chun
Shou, Wenying
author_facet Hart, Samuel Frederick Mock
Chen, Chi-Chun
Shou, Wenying
author_sort Hart, Samuel Frederick Mock
collection PubMed
description Cooperation, paying a cost to benefit others, is widespread. Cooperation can be promoted by pleiotropic ‘win-win’ mutations which directly benefit self (self-serving) and partner (partner-serving). Previously, we showed that partner-serving should be defined as increased benefit supply rate per intake benefit. Here, we report that win-win mutations can rapidly evolve even under conditions unfavorable for cooperation. Specifically, in a well-mixed environment we evolved engineered yeast cooperative communities where two strains exchanged costly metabolites, lysine and hypoxanthine. Among cells that consumed lysine and released hypoxanthine, ecm21 mutations repeatedly arose. ecm21 is self-serving, improving self’s growth rate in limiting lysine. ecm21 is also partner-serving, increasing hypoxanthine release rate per lysine consumption and the steady state growth rate of partner and of community. ecm21 also arose in monocultures evolving in lysine-limited chemostats. Thus, even without any history of cooperation or pressure to maintain cooperation, pleiotropic win-win mutations may readily evolve to promote cooperation.
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spelling pubmed-81842122021-06-09 Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions Hart, Samuel Frederick Mock Chen, Chi-Chun Shou, Wenying eLife Ecology Cooperation, paying a cost to benefit others, is widespread. Cooperation can be promoted by pleiotropic ‘win-win’ mutations which directly benefit self (self-serving) and partner (partner-serving). Previously, we showed that partner-serving should be defined as increased benefit supply rate per intake benefit. Here, we report that win-win mutations can rapidly evolve even under conditions unfavorable for cooperation. Specifically, in a well-mixed environment we evolved engineered yeast cooperative communities where two strains exchanged costly metabolites, lysine and hypoxanthine. Among cells that consumed lysine and released hypoxanthine, ecm21 mutations repeatedly arose. ecm21 is self-serving, improving self’s growth rate in limiting lysine. ecm21 is also partner-serving, increasing hypoxanthine release rate per lysine consumption and the steady state growth rate of partner and of community. ecm21 also arose in monocultures evolving in lysine-limited chemostats. Thus, even without any history of cooperation or pressure to maintain cooperation, pleiotropic win-win mutations may readily evolve to promote cooperation. eLife Sciences Publications, Ltd 2021-01-27 /pmc/articles/PMC8184212/ /pubmed/33501915 http://dx.doi.org/10.7554/eLife.57838 Text en © 2021, Hart et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Ecology
Hart, Samuel Frederick Mock
Chen, Chi-Chun
Shou, Wenying
Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions
title Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions
title_full Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions
title_fullStr Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions
title_full_unstemmed Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions
title_short Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions
title_sort pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions
topic Ecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184212/
https://www.ncbi.nlm.nih.gov/pubmed/33501915
http://dx.doi.org/10.7554/eLife.57838
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