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Symptoms in patients with asthma infected by SARS-CoV-2

INTRODUCTION: Organ tropism of SARS-CoV-2 to the respiratory tract could potentially aggravate asthma. The susceptibility of patients with asthma to develop an exacerbation when they are infected with SARS-CoV-2 is unknown. We aimed to investigate the symptoms presented in patients with asthma who b...

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Autores principales: Garcia-Pachon, Eduardo, Ruiz-Alcaraz, Sandra, Baeza-Martinez, Carlos, Zamora-Molina, Lucia, Soler-Sempere, Maria J., Padilla-Navas, Isabel, Grau-Delgado, Justo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184356/
https://www.ncbi.nlm.nih.gov/pubmed/34126579
http://dx.doi.org/10.1016/j.rmed.2021.106495
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author Garcia-Pachon, Eduardo
Ruiz-Alcaraz, Sandra
Baeza-Martinez, Carlos
Zamora-Molina, Lucia
Soler-Sempere, Maria J.
Padilla-Navas, Isabel
Grau-Delgado, Justo
author_facet Garcia-Pachon, Eduardo
Ruiz-Alcaraz, Sandra
Baeza-Martinez, Carlos
Zamora-Molina, Lucia
Soler-Sempere, Maria J.
Padilla-Navas, Isabel
Grau-Delgado, Justo
author_sort Garcia-Pachon, Eduardo
collection PubMed
description INTRODUCTION: Organ tropism of SARS-CoV-2 to the respiratory tract could potentially aggravate asthma. The susceptibility of patients with asthma to develop an exacerbation when they are infected with SARS-CoV-2 is unknown. We aimed to investigate the symptoms presented in patients with asthma who became infected with SARS-CoV-2. METHODS AND RESULTS: All patients over 14 years of age who tested positive for SARS-CoV-2 (by RT-PCR) were included (n = 2995). In patients with asthma (n = 77, 2.6%; 44 females), symptoms, therapy and phenotype were recorded. Seventeen (22%) patients had mild asthma, 55 (71%) moderate and five severe (6%). Twenty-six patients with asthma (34%) were asymptomatic, 34 (44%) developed symptoms but did not require hospital admission, and 17 (22%) were hospitalised. One patient was admitted because of asthma exacerbation without pneumonia or other symptoms. Ten patients (13%) had wheezes (six with pneumonia). Comparison of wheezing between patients with non-T2 asthma and the rest of the patients was statistically significant, (p < 0.001). CONCLUSIONS: SARS-CoV-2 infection is not a significant cause of asthma exacerbation, although some patients may present wheezing, especially in cases of pneumonia. The severity of asthma does not seem to be associated with symptoms of the disease.
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spelling pubmed-81843562021-06-08 Symptoms in patients with asthma infected by SARS-CoV-2 Garcia-Pachon, Eduardo Ruiz-Alcaraz, Sandra Baeza-Martinez, Carlos Zamora-Molina, Lucia Soler-Sempere, Maria J. Padilla-Navas, Isabel Grau-Delgado, Justo Respir Med Short Communication INTRODUCTION: Organ tropism of SARS-CoV-2 to the respiratory tract could potentially aggravate asthma. The susceptibility of patients with asthma to develop an exacerbation when they are infected with SARS-CoV-2 is unknown. We aimed to investigate the symptoms presented in patients with asthma who became infected with SARS-CoV-2. METHODS AND RESULTS: All patients over 14 years of age who tested positive for SARS-CoV-2 (by RT-PCR) were included (n = 2995). In patients with asthma (n = 77, 2.6%; 44 females), symptoms, therapy and phenotype were recorded. Seventeen (22%) patients had mild asthma, 55 (71%) moderate and five severe (6%). Twenty-six patients with asthma (34%) were asymptomatic, 34 (44%) developed symptoms but did not require hospital admission, and 17 (22%) were hospitalised. One patient was admitted because of asthma exacerbation without pneumonia or other symptoms. Ten patients (13%) had wheezes (six with pneumonia). Comparison of wheezing between patients with non-T2 asthma and the rest of the patients was statistically significant, (p < 0.001). CONCLUSIONS: SARS-CoV-2 infection is not a significant cause of asthma exacerbation, although some patients may present wheezing, especially in cases of pneumonia. The severity of asthma does not seem to be associated with symptoms of the disease. Elsevier Ltd. 2021 2021-06-08 /pmc/articles/PMC8184356/ /pubmed/34126579 http://dx.doi.org/10.1016/j.rmed.2021.106495 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Garcia-Pachon, Eduardo
Ruiz-Alcaraz, Sandra
Baeza-Martinez, Carlos
Zamora-Molina, Lucia
Soler-Sempere, Maria J.
Padilla-Navas, Isabel
Grau-Delgado, Justo
Symptoms in patients with asthma infected by SARS-CoV-2
title Symptoms in patients with asthma infected by SARS-CoV-2
title_full Symptoms in patients with asthma infected by SARS-CoV-2
title_fullStr Symptoms in patients with asthma infected by SARS-CoV-2
title_full_unstemmed Symptoms in patients with asthma infected by SARS-CoV-2
title_short Symptoms in patients with asthma infected by SARS-CoV-2
title_sort symptoms in patients with asthma infected by sars-cov-2
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184356/
https://www.ncbi.nlm.nih.gov/pubmed/34126579
http://dx.doi.org/10.1016/j.rmed.2021.106495
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