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Prion-derived tetrapeptide stabilizes thermolabile insulin via conformational trapping

Unfolding followed by fibrillation of insulin even in the presence of various excipients grappled with restricted clinical application. Thus, there is an unmet need for better thermostable, nontoxic molecules to preserve bioactive insulin under varying physiochemical perturbations. In search of cros...

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Detalles Bibliográficos
Autores principales:	Mukherjee, Meghomukta, Das, Debajyoti, Sarkar, Jit, Banerjee, Nilanjan, Jana, Jagannath, Bhat, Jyotsna, Reddy G, Jithender, Bharatam, Jagadeesh, Chattopadhyay, Samit, Chatterjee, Subhrangsu, Chakrabarti, Partha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184657/ https://www.ncbi.nlm.nih.gov/pubmed/34142060 http://dx.doi.org/10.1016/j.isci.2021.102573

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