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REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway

Persistent acinar to ductal metaplasia (ADM) is a recently recognized precursor of pancreatic ductal adenocarcinoma (PDAC). Here we show that the ADM area of human pancreas tissue adjacent to PDAC expresses significantly higher levels of regenerating protein 3A (REG3A). Exogenous REG3A and its mouse...

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Detalles Bibliográficos
Autores principales:	Zhang, Huairong, Corredor, Andrea Liliam Gomez, Messina-Pacheco, Julia, Li, Qing, Zogopoulos, George, Kaddour, Nancy, Wang, Yifan, Shi, Bing-yin, Gregorieff, Alex, Liu, Jun-li, Gao, Zu-hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184755/ https://www.ncbi.nlm.nih.gov/pubmed/34099862 http://dx.doi.org/10.1038/s42003-021-02193-z

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