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SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions
Due to the high rate of transmissibility, Brazil became the new COVID-19 outbreak epicenter and, since then, is being monitored to understand how SARS-CoV-2 mutates and spreads. We combined genomic and structural analysis to evaluate genomes isolated from different regions of Brazil and show that th...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184806/ https://www.ncbi.nlm.nih.gov/pubmed/34099808 http://dx.doi.org/10.1038/s41598-021-91585-6 |
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author | Timmers, Luis Fernando Saraiva Macedo Peixoto, Julia Vasconcellos Ducati, Rodrigo Gay Bachega, José Fernando Ruggiero de Mattos Pereira, Leandro Caceres, Rafael Andrade Majolo, Fernanda da Silva, Guilherme Liberato Anton, Débora Bublitz Dellagostin, Odir Antônio Henriques, João Antônio Pegas Xavier, Léder Leal Goettert, Márcia Inês Laufer, Stefan |
author_facet | Timmers, Luis Fernando Saraiva Macedo Peixoto, Julia Vasconcellos Ducati, Rodrigo Gay Bachega, José Fernando Ruggiero de Mattos Pereira, Leandro Caceres, Rafael Andrade Majolo, Fernanda da Silva, Guilherme Liberato Anton, Débora Bublitz Dellagostin, Odir Antônio Henriques, João Antônio Pegas Xavier, Léder Leal Goettert, Márcia Inês Laufer, Stefan |
author_sort | Timmers, Luis Fernando Saraiva Macedo |
collection | PubMed |
description | Due to the high rate of transmissibility, Brazil became the new COVID-19 outbreak epicenter and, since then, is being monitored to understand how SARS-CoV-2 mutates and spreads. We combined genomic and structural analysis to evaluate genomes isolated from different regions of Brazil and show that the most prevalent mutations were located in the S, N, ORF3a and ORF6 genes, which are involved in different stages of viral life cycle and its interaction with the host cells. Structural analysis brought to light the positions of these mutations on protein structures, contributing towards studies of selective structure-based drug discovery and vaccine development. |
format | Online Article Text |
id | pubmed-8184806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81848062021-06-08 SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions Timmers, Luis Fernando Saraiva Macedo Peixoto, Julia Vasconcellos Ducati, Rodrigo Gay Bachega, José Fernando Ruggiero de Mattos Pereira, Leandro Caceres, Rafael Andrade Majolo, Fernanda da Silva, Guilherme Liberato Anton, Débora Bublitz Dellagostin, Odir Antônio Henriques, João Antônio Pegas Xavier, Léder Leal Goettert, Márcia Inês Laufer, Stefan Sci Rep Article Due to the high rate of transmissibility, Brazil became the new COVID-19 outbreak epicenter and, since then, is being monitored to understand how SARS-CoV-2 mutates and spreads. We combined genomic and structural analysis to evaluate genomes isolated from different regions of Brazil and show that the most prevalent mutations were located in the S, N, ORF3a and ORF6 genes, which are involved in different stages of viral life cycle and its interaction with the host cells. Structural analysis brought to light the positions of these mutations on protein structures, contributing towards studies of selective structure-based drug discovery and vaccine development. Nature Publishing Group UK 2021-06-07 /pmc/articles/PMC8184806/ /pubmed/34099808 http://dx.doi.org/10.1038/s41598-021-91585-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Timmers, Luis Fernando Saraiva Macedo Peixoto, Julia Vasconcellos Ducati, Rodrigo Gay Bachega, José Fernando Ruggiero de Mattos Pereira, Leandro Caceres, Rafael Andrade Majolo, Fernanda da Silva, Guilherme Liberato Anton, Débora Bublitz Dellagostin, Odir Antônio Henriques, João Antônio Pegas Xavier, Léder Leal Goettert, Márcia Inês Laufer, Stefan SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions |
title | SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions |
title_full | SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions |
title_fullStr | SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions |
title_full_unstemmed | SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions |
title_short | SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions |
title_sort | sars-cov-2 mutations in brazil: from genomics to putative clinical conditions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184806/ https://www.ncbi.nlm.nih.gov/pubmed/34099808 http://dx.doi.org/10.1038/s41598-021-91585-6 |
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