High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites

Binding of mammalian transcription factors (TFs) to regulatory regions is hindered by chromatin compaction and DNA methylation of their binding sites. Nevertheless, pioneer transcription factors (PFs), a distinct class of TFs, have the ability to access nucleosomal DNA, leading to nucleosome remodel...

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Detalles Bibliográficos
Autores principales: Vanzan, Ludovica, Soldati, Hadrien, Ythier, Victor, Anand, Santosh, Braun, Simon M. G., Francis, Nicole, Murr, Rabih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184831/
https://www.ncbi.nlm.nih.gov/pubmed/34099689
http://dx.doi.org/10.1038/s41467-021-23630-x

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