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Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure

Frailty is a common comorbidity associated with adverse events in patients with heart failure, and early recognition is key to improving its management. We hypothesized that the AST to ALT ratio (AAR) could be a marker of frailty in patients with heart failure. Data from the FRAGILE-HF study were an...

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Autores principales: Maeda, Daichi, Kagiyama, Nobuyuki, Jujo, Kentaro, Saito, Kazuya, Kamiya, Kentaro, Saito, Hiroshi, Ogasahara, Yuki, Maekawa, Emi, Konishi, Masaaki, Kitai, Takeshi, Iwata, Kentaro, Wada, Hiroshi, Hiki, Masaru, Dotare, Taishi, Sunayama, Tsutomu, Kasai, Takatoshi, Nagamatsu, Hirofumi, Ozawa, Tetsuya, Izawa, Katsuya, Yamamoto, Shuhei, Aizawa, Naoki, Yonezawa, Ryusuke, Oka, Kazuhiro, Momomura, Shin-ichi, Matsue, Yuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184951/
https://www.ncbi.nlm.nih.gov/pubmed/34099767
http://dx.doi.org/10.1038/s41598-021-91368-z
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author Maeda, Daichi
Kagiyama, Nobuyuki
Jujo, Kentaro
Saito, Kazuya
Kamiya, Kentaro
Saito, Hiroshi
Ogasahara, Yuki
Maekawa, Emi
Konishi, Masaaki
Kitai, Takeshi
Iwata, Kentaro
Wada, Hiroshi
Hiki, Masaru
Dotare, Taishi
Sunayama, Tsutomu
Kasai, Takatoshi
Nagamatsu, Hirofumi
Ozawa, Tetsuya
Izawa, Katsuya
Yamamoto, Shuhei
Aizawa, Naoki
Yonezawa, Ryusuke
Oka, Kazuhiro
Momomura, Shin-ichi
Matsue, Yuya
author_facet Maeda, Daichi
Kagiyama, Nobuyuki
Jujo, Kentaro
Saito, Kazuya
Kamiya, Kentaro
Saito, Hiroshi
Ogasahara, Yuki
Maekawa, Emi
Konishi, Masaaki
Kitai, Takeshi
Iwata, Kentaro
Wada, Hiroshi
Hiki, Masaru
Dotare, Taishi
Sunayama, Tsutomu
Kasai, Takatoshi
Nagamatsu, Hirofumi
Ozawa, Tetsuya
Izawa, Katsuya
Yamamoto, Shuhei
Aizawa, Naoki
Yonezawa, Ryusuke
Oka, Kazuhiro
Momomura, Shin-ichi
Matsue, Yuya
author_sort Maeda, Daichi
collection PubMed
description Frailty is a common comorbidity associated with adverse events in patients with heart failure, and early recognition is key to improving its management. We hypothesized that the AST to ALT ratio (AAR) could be a marker of frailty in patients with heart failure. Data from the FRAGILE-HF study were analyzed. A total of 1327 patients aged ≥ 65 years hospitalized with heart failure were categorized into three groups based on their AAR at discharge: low AAR (AAR < 1.16, n = 434); middle AAR (1.16 ≤ AAR < 1.70, n = 487); high AAR (AAR ≥ 1.70, n = 406). The primary endpoint was one-year mortality. The association between AAR and physical function was also assessed. High AAR was associated with lower short physical performance battery and shorter 6-min walk distance, and these associations were independent of age and sex. Logistic regression analysis revealed that high AAR was an independent marker of physical frailty after adjustment for age, sex and body mass index. During follow-up, all-cause death occurred in 161 patients. After adjusting for confounding factors, high AAR was associated with all-cause death (low AAR vs. high AAR, hazard ratio: 1.57, 95% confidence interval, 1.02–2.42; P = 0.040). In conclusion, AAR is a marker of frailty and prognostic for all-cause mortality in older patients with heart failure.
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spelling pubmed-81849512021-06-08 Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure Maeda, Daichi Kagiyama, Nobuyuki Jujo, Kentaro Saito, Kazuya Kamiya, Kentaro Saito, Hiroshi Ogasahara, Yuki Maekawa, Emi Konishi, Masaaki Kitai, Takeshi Iwata, Kentaro Wada, Hiroshi Hiki, Masaru Dotare, Taishi Sunayama, Tsutomu Kasai, Takatoshi Nagamatsu, Hirofumi Ozawa, Tetsuya Izawa, Katsuya Yamamoto, Shuhei Aizawa, Naoki Yonezawa, Ryusuke Oka, Kazuhiro Momomura, Shin-ichi Matsue, Yuya Sci Rep Article Frailty is a common comorbidity associated with adverse events in patients with heart failure, and early recognition is key to improving its management. We hypothesized that the AST to ALT ratio (AAR) could be a marker of frailty in patients with heart failure. Data from the FRAGILE-HF study were analyzed. A total of 1327 patients aged ≥ 65 years hospitalized with heart failure were categorized into three groups based on their AAR at discharge: low AAR (AAR < 1.16, n = 434); middle AAR (1.16 ≤ AAR < 1.70, n = 487); high AAR (AAR ≥ 1.70, n = 406). The primary endpoint was one-year mortality. The association between AAR and physical function was also assessed. High AAR was associated with lower short physical performance battery and shorter 6-min walk distance, and these associations were independent of age and sex. Logistic regression analysis revealed that high AAR was an independent marker of physical frailty after adjustment for age, sex and body mass index. During follow-up, all-cause death occurred in 161 patients. After adjusting for confounding factors, high AAR was associated with all-cause death (low AAR vs. high AAR, hazard ratio: 1.57, 95% confidence interval, 1.02–2.42; P = 0.040). In conclusion, AAR is a marker of frailty and prognostic for all-cause mortality in older patients with heart failure. Nature Publishing Group UK 2021-06-07 /pmc/articles/PMC8184951/ /pubmed/34099767 http://dx.doi.org/10.1038/s41598-021-91368-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Maeda, Daichi
Kagiyama, Nobuyuki
Jujo, Kentaro
Saito, Kazuya
Kamiya, Kentaro
Saito, Hiroshi
Ogasahara, Yuki
Maekawa, Emi
Konishi, Masaaki
Kitai, Takeshi
Iwata, Kentaro
Wada, Hiroshi
Hiki, Masaru
Dotare, Taishi
Sunayama, Tsutomu
Kasai, Takatoshi
Nagamatsu, Hirofumi
Ozawa, Tetsuya
Izawa, Katsuya
Yamamoto, Shuhei
Aizawa, Naoki
Yonezawa, Ryusuke
Oka, Kazuhiro
Momomura, Shin-ichi
Matsue, Yuya
Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure
title Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure
title_full Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure
title_fullStr Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure
title_full_unstemmed Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure
title_short Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure
title_sort aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184951/
https://www.ncbi.nlm.nih.gov/pubmed/34099767
http://dx.doi.org/10.1038/s41598-021-91368-z
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