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Electricity-producing Staphylococcus epidermidis counteracts Cutibacterium acnes
Staphylococcus epidermidis (S. epidermidis) ATCC 12228 was incubated with 2% polyethylene glycol (PEG)-8 Laurate to yield electricity which was measured by a voltage difference between electrodes. Production of electron was validated by a Ferrozine assay. The anti-Cutibacterium acnes (C. acnes) acti...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184966/ https://www.ncbi.nlm.nih.gov/pubmed/34099817 http://dx.doi.org/10.1038/s41598-021-91398-7 |
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author | Marito, Shinta Keshari, Sunita Traisaeng, Supitchaya My, Do Thi Tra Balasubramaniam, Arun Adi, Prakoso Hsieh, Ming-Fa Herr, Deron Raymond Huang, Chun-Ming |
author_facet | Marito, Shinta Keshari, Sunita Traisaeng, Supitchaya My, Do Thi Tra Balasubramaniam, Arun Adi, Prakoso Hsieh, Ming-Fa Herr, Deron Raymond Huang, Chun-Ming |
author_sort | Marito, Shinta |
collection | PubMed |
description | Staphylococcus epidermidis (S. epidermidis) ATCC 12228 was incubated with 2% polyethylene glycol (PEG)-8 Laurate to yield electricity which was measured by a voltage difference between electrodes. Production of electron was validated by a Ferrozine assay. The anti-Cutibacterium acnes (C. acnes) activity of electrogenic S. epidermidis was assessed in vitro and in vivo. The voltage change (~ 4.4 mV) reached a peak 60 min after pipetting S. epidermidis plus 2% PEG-8 Laurate onto anodes. The electricity produced by S. epidermidis caused significant growth attenuation and cell lysis of C. acnes. Intradermal injection of C. acnes and S. epidermidis plus PEG-8 Laurate into the mouse ear considerably suppressed the growth of C. acnes. This suppressive effect was noticeably reversed when cyclophilin A of S. epidermidis was inhibited, indicating the essential role of cyclophilin A in electricity production of S. epidermidis against C. acnes. In summary, we demonstrate for the first time that skin S. epidermidis, in the presence of PEG-8 Laurate, can mediate cyclophilin A to elicit an electrical current that has anti-C. acnes effects. Electricity generated by S. epidermidis may confer immediate innate immunity in acne lesions to rein in the overgrowth of C. acnes at the onset of acne vulgaris. |
format | Online Article Text |
id | pubmed-8184966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81849662021-06-08 Electricity-producing Staphylococcus epidermidis counteracts Cutibacterium acnes Marito, Shinta Keshari, Sunita Traisaeng, Supitchaya My, Do Thi Tra Balasubramaniam, Arun Adi, Prakoso Hsieh, Ming-Fa Herr, Deron Raymond Huang, Chun-Ming Sci Rep Article Staphylococcus epidermidis (S. epidermidis) ATCC 12228 was incubated with 2% polyethylene glycol (PEG)-8 Laurate to yield electricity which was measured by a voltage difference between electrodes. Production of electron was validated by a Ferrozine assay. The anti-Cutibacterium acnes (C. acnes) activity of electrogenic S. epidermidis was assessed in vitro and in vivo. The voltage change (~ 4.4 mV) reached a peak 60 min after pipetting S. epidermidis plus 2% PEG-8 Laurate onto anodes. The electricity produced by S. epidermidis caused significant growth attenuation and cell lysis of C. acnes. Intradermal injection of C. acnes and S. epidermidis plus PEG-8 Laurate into the mouse ear considerably suppressed the growth of C. acnes. This suppressive effect was noticeably reversed when cyclophilin A of S. epidermidis was inhibited, indicating the essential role of cyclophilin A in electricity production of S. epidermidis against C. acnes. In summary, we demonstrate for the first time that skin S. epidermidis, in the presence of PEG-8 Laurate, can mediate cyclophilin A to elicit an electrical current that has anti-C. acnes effects. Electricity generated by S. epidermidis may confer immediate innate immunity in acne lesions to rein in the overgrowth of C. acnes at the onset of acne vulgaris. Nature Publishing Group UK 2021-06-07 /pmc/articles/PMC8184966/ /pubmed/34099817 http://dx.doi.org/10.1038/s41598-021-91398-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Marito, Shinta Keshari, Sunita Traisaeng, Supitchaya My, Do Thi Tra Balasubramaniam, Arun Adi, Prakoso Hsieh, Ming-Fa Herr, Deron Raymond Huang, Chun-Ming Electricity-producing Staphylococcus epidermidis counteracts Cutibacterium acnes |
title | Electricity-producing Staphylococcus epidermidis counteracts Cutibacterium acnes |
title_full | Electricity-producing Staphylococcus epidermidis counteracts Cutibacterium acnes |
title_fullStr | Electricity-producing Staphylococcus epidermidis counteracts Cutibacterium acnes |
title_full_unstemmed | Electricity-producing Staphylococcus epidermidis counteracts Cutibacterium acnes |
title_short | Electricity-producing Staphylococcus epidermidis counteracts Cutibacterium acnes |
title_sort | electricity-producing staphylococcus epidermidis counteracts cutibacterium acnes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184966/ https://www.ncbi.nlm.nih.gov/pubmed/34099817 http://dx.doi.org/10.1038/s41598-021-91398-7 |
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