Design, synthesis, molecular docking, and in vitro α-glucosidase inhibitory activities of novel 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines against yeast and rat α-glucosidase

In an attempt to find novel, potent α-glucosidase inhibitors, a library of poly-substituted 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines 3a–ag have been synthesized through heating a mixture of 2-aminobenzimidazoles 1 and α-azidochalcone 2 under the mild conditions. This efficient, facile p...

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Detalles Bibliográficos
Autores principales: Peytam, Fariba, Takalloobanafshi, Ghazaleh, Saadattalab, Toktam, Norouzbahari, Maryam, Emamgholipour, Zahra, Moghimi, Setareh, Firoozpour, Loghman, Bijanzadeh, Hamid Reza, Faramarzi, Mohammad Ali, Mojtabavi, Somayeh, Rashidi-Ranjbar, Parviz, Karima, Saeed, Pakraad, Roya, Foroumadi, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184976/
https://www.ncbi.nlm.nih.gov/pubmed/34099819
http://dx.doi.org/10.1038/s41598-021-91473-z

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