The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets

Platelets contribute to the regulation of tissue neovascularization, although the specific factors underlying this function are unknown. Here, we identified the complement anaphylatoxin C5a-mediated activation of C5a receptor 1 (C5aR1) on platelets as a negative regulatory mechanism of vessel format...

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Detalles Bibliográficos
Autores principales: Nording, Henry, Baron, Lasse, Haberthür, David, Emschermann, Frederic, Mezger, Matthias, Sauter, Manuela, Sauter, Reinhard, Patzelt, Johannes, Knoepp, Kai, Nording, Anne, Meusel, Moritz, Meyer-Saraei, Roza, Hlushchuk, Ruslan, Sedding, Daniel, Borst, Oliver, Eitel, Ingo, Karsten, Christian M., Feil, Robert, Pichler, Bernd, Erdmann, Jeanette, Verschoor, Admar, Chavakis, Emmanouil, Chavakis, Triantafyllos, von Hundelshausen, Philipp, Köhl, Jörg, Gawaz, Meinrad, Langer, Harald F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185003/
https://www.ncbi.nlm.nih.gov/pubmed/34099640
http://dx.doi.org/10.1038/s41467-021-23499-w

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