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Odor Recognition Memory in Parkinson's Disease: A Systematic Review

Olfactory impairment is a central non-motor symptom in Parkinson's disease (PD). Previous studies have demonstrated that olfactory dysfunction is associated with mental illness and impaired cognition. The frequently investigated olfactory functions are odor detection, discrimination, and identi...

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Autores principales: Eek, Tom, Larsson, Maria, Dizdar, Nil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185042/
https://www.ncbi.nlm.nih.gov/pubmed/34113245
http://dx.doi.org/10.3389/fnagi.2021.625171
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author Eek, Tom
Larsson, Maria
Dizdar, Nil
author_facet Eek, Tom
Larsson, Maria
Dizdar, Nil
author_sort Eek, Tom
collection PubMed
description Olfactory impairment is a central non-motor symptom in Parkinson's disease (PD). Previous studies have demonstrated that olfactory dysfunction is associated with mental illness and impaired cognition. The frequently investigated olfactory functions are odor detection, discrimination, and identification. However, few studies have focused on odor recognition memory (ORM). ORM tasks involves episodic memory which therefore can facilitate the detection of dementia among patients with PD and consequently adjust their treatment. Thus, the aim of this systematic review is to summarize the existing research on ORM in PD. Databases and reference lists were used for data collection. Studies were included in the review if they met the eligibility criteria derived from the PICOS-framework. Quality evaluation of the studies was based on the STROBE-statement. Six studies with small samples were included in the analysis which demonstrated the scarce research on the subject. The studies targeting ORM were heterogenous and involved two main tasks: odor recognition and odor matching. The synthesis of the data demonstrated that PD patients performed significantly lower than controls on both tasks, especially on odor matching task. Only the odor recognition task exhibited a difference between patients with PD vs. Alzheimer's disease (AD). PD patients performed significantly better than AD patients. The findings based on the available limited data support the notion that odor recognition task can be of importance in identifying Parkinson's disease dementia (PDD). To investigate this hypothesis, future research needs to include larger samples of PD, PDD and AD patients executing the same odor recognition task.
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spelling pubmed-81850422021-06-09 Odor Recognition Memory in Parkinson's Disease: A Systematic Review Eek, Tom Larsson, Maria Dizdar, Nil Front Aging Neurosci Neuroscience Olfactory impairment is a central non-motor symptom in Parkinson's disease (PD). Previous studies have demonstrated that olfactory dysfunction is associated with mental illness and impaired cognition. The frequently investigated olfactory functions are odor detection, discrimination, and identification. However, few studies have focused on odor recognition memory (ORM). ORM tasks involves episodic memory which therefore can facilitate the detection of dementia among patients with PD and consequently adjust their treatment. Thus, the aim of this systematic review is to summarize the existing research on ORM in PD. Databases and reference lists were used for data collection. Studies were included in the review if they met the eligibility criteria derived from the PICOS-framework. Quality evaluation of the studies was based on the STROBE-statement. Six studies with small samples were included in the analysis which demonstrated the scarce research on the subject. The studies targeting ORM were heterogenous and involved two main tasks: odor recognition and odor matching. The synthesis of the data demonstrated that PD patients performed significantly lower than controls on both tasks, especially on odor matching task. Only the odor recognition task exhibited a difference between patients with PD vs. Alzheimer's disease (AD). PD patients performed significantly better than AD patients. The findings based on the available limited data support the notion that odor recognition task can be of importance in identifying Parkinson's disease dementia (PDD). To investigate this hypothesis, future research needs to include larger samples of PD, PDD and AD patients executing the same odor recognition task. Frontiers Media S.A. 2021-05-25 /pmc/articles/PMC8185042/ /pubmed/34113245 http://dx.doi.org/10.3389/fnagi.2021.625171 Text en Copyright © 2021 Eek, Larsson and Dizdar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Eek, Tom
Larsson, Maria
Dizdar, Nil
Odor Recognition Memory in Parkinson's Disease: A Systematic Review
title Odor Recognition Memory in Parkinson's Disease: A Systematic Review
title_full Odor Recognition Memory in Parkinson's Disease: A Systematic Review
title_fullStr Odor Recognition Memory in Parkinson's Disease: A Systematic Review
title_full_unstemmed Odor Recognition Memory in Parkinson's Disease: A Systematic Review
title_short Odor Recognition Memory in Parkinson's Disease: A Systematic Review
title_sort odor recognition memory in parkinson's disease: a systematic review
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185042/
https://www.ncbi.nlm.nih.gov/pubmed/34113245
http://dx.doi.org/10.3389/fnagi.2021.625171
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