PGC7 promotes tumor oncogenic dedifferentiation through remodeling DNA methylation pattern for key developmental transcription factors

Poorly differentiated tumors usually exhibit phenotypes similar to that of their developmental precursor cells. Tumor cells that acquire the lineage progenitor cells feature usually exploit developmental signaling to potentiate cancer progression. However, the underlying molecular events remain elus...

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Detalles Bibliográficos
Autores principales: Yan, Qian, Zhang, Yu, Fang, Xiaona, Liu, Beilei, Wong, Tin Lok, Gong, Lanqi, Liu, Shan, Yu, Dandan, Liu, Ming, Jiang, Lingxi, Wang, Xia, Wei, Ting, Jia, Yongxu, Li, Lei, Sun, Liangzhan, Tang, Ying, Zhou, Ningning, Yuan, Yun-Fei, Li, Yan, Ma, Stephanie, Guan, Xin-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185079/
https://www.ncbi.nlm.nih.gov/pubmed/33500560
http://dx.doi.org/10.1038/s41418-020-00726-3

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