Cargando…

Sam68 promotes hepatic gluconeogenesis via CRTC2

Hepatic gluconeogenesis is essential for glucose homeostasis and also a therapeutic target for type 2 diabetes, but its mechanism is incompletely understood. Here, we report that Sam68, an RNA-binding adaptor protein and Src kinase substrate, is a novel regulator of hepatic gluconeogenesis. Both glo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qiao, Aijun, Zhou, Junlan, Xu, Shiyue, Ma, Wenxia, Boriboun, Chan, Kim, Teayoun, Yan, Baolong, Deng, Jianxin, Yang, Liu, Zhang, Eric, Song, Yuhua, Ma, Yongchao C., Richard, Stephane, Zhang, Chunxiang, Qiu, Hongyu, Habegger, Kirk M., Zhang, Jianyi, Qin, Gangjian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185084/ https://www.ncbi.nlm.nih.gov/pubmed/34099657 http://dx.doi.org/10.1038/s41467-021-23624-9

Ejemplares similares

Hepatic Sam68 Regulates Systemic Glucose Homeostasis and Insulin Sensitivity
por: Qiao, Aijun, et al.
Publicado: (2022)

Ablation of lncRNA Miat attenuates pathological hypertrophy and heart failure
por: Yang, Liu, et al.
Publicado: (2021)

Suppression of CRTC2-mediated hepatic gluconeogenesis by TRAF6 contributes to hypoglycemia in septic shock
por: Lv, Sihan, et al.
Publicado: (2016)

The CREB Coactivator CRTC2 Links Hepatic ER Stress and Fasting Gluconeogenesis
por: Wang, Yiguo, et al.
Publicado: (2009)

Analysis of mesenchymal stem cell proteomes in situ in the ischemic heart
por: Han, Dunzheng, et al.
Publicado: (2020)

SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells
por: Wang, Chang, et al.
Publicado: (2020)

Utility of SAM68 in the progression and prognosis for bladder cancer
por: Zhang, Zhiling, et al.
Publicado: (2015)

ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs
por: Pankivskyi, S., et al.
Publicado: (2020)

Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma
por: Chen, Shuwei, et al.
Publicado: (2016)

Stay lean without dieting: Lose Sam68
por: Huot, Marc-Étienne, et al.
Publicado: (2012)

Sam68 is a novel marker for aggressive neuroblastoma
por: Zhao, Xiaohong, et al.
Publicado: (2013)

Role of Sam68 in Post-Transcriptional Gene Regulation
por: Sánchez-Jiménez, Flora, et al.
Publicado: (2013)

High expression of Sam68 in sacral chordomas is associated with worse clinical outcomes
por: Wen, Hai, et al.
Publicado: (2017)

Sam68 mediates high glucose-induced podocyte apoptosis through modulation of Bax/Bcl-2
por: Chen, Yuyu, et al.
Publicado: (2019)

Role of Sam68 in Sunitinib induced renal cell carcinoma apoptosis
por: Wu, Zeshen, et al.
Publicado: (2022)

Interactions between SAM and the 5′ UTR mRNA of the sam1 gene regulate translation in S. pombe
por: Zhang, Xuhui, et al.
Publicado: (2020)

Sam68 is a novel marker for aggressive neuroblastoma [Corrigendum]
Publicado: (2014)

SAM68: Signal Transduction and RNA Metabolism in Human Cancer
por: Frisone, Paola, et al.
Publicado: (2015)

Sam68 is a regulator of Toll-like receptor signaling
por: Tomalka, Jeffrey A, et al.
Publicado: (2017)

Clinical significance and effect of Sam68 expression in gastric cancer
por: Xiao, Jinzhang, et al.
Publicado: (2018)

Sam68 is required for the growth and survival of nonmelanoma skin cancer
por: Fu, Kai, et al.
Publicado: (2019)

Validating Sam68 expression and protein level in breast cancer
por: Khudhair, Muneer Kadhum, et al.
Publicado: (2023)

Sam68 exerts separable effects on cell cycle progression and apoptosis
por: Taylor, Stephen J, et al.
Publicado: (2004)

Sam68 is absolutely required for Rev function and HIV-1 production
por: Modem, Suhasini, et al.
Publicado: (2005)

Sam68 is absolutely required for Rev function and HIV-1 production
por: Modem, Suhasini, et al.
Publicado: (2005)

SAM68 is required for regulation of Pumilio by the NORAD long noncoding RNA
por: Tichon, Ailone, et al.
Publicado: (2018)

The p53 status can influence the role of Sam68 in tumorigenesis
por: Li, Naomi, et al.
Publicado: (2016)

Leptin, Adiponectin, and Sam68 in Bone Metastasis from Breast Cancer
por: Maroni, Paola
Publicado: (2020)

Pharmacological targeting of Sam68 functions in colorectal cancer stem cells
por: Masibag, Angelique N., et al.
Publicado: (2021)

Novel role for the CRTC2 in lipid homeostasis
por: Matsuzaka, Takashi, et al.
Publicado: (2016)

Activation of the adipocyte CREB/CRTC pathway in obesity
por: Yoon, Young-Sil, et al.
Publicado: (2021)

The long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68
por: Wang, Xue, et al.
Publicado: (2018)

The CRTC-CREB axis functions as a transcriptional sensor to protect against proteotoxic stress in Drosophila
por: Yin, Youjie, et al.
Publicado: (2022)

Unraveling the Regulation of Hepatic Gluconeogenesis
por: Zhang, Xueping, et al.
Publicado: (2019)

The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x
por: Paronetto, Maria Paola, et al.
Publicado: (2007)

Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68
por: Feracci, Mikael, et al.
Publicado: (2016)

Sam68 Mediates the Activation of Insulin and Leptin Signalling in Breast Cancer Cells
por: Pérez-Pérez, Antonio, et al.
Publicado: (2016)

Sam68 functions as a transcriptional coactivator of the p53 tumor suppressor
por: Li, Naomi, et al.
Publicado: (2016)

Sam68 is Overexpressed in Epithelial Ovarian Cancer and Promotes Tumor Cell Proliferation
por: Dong, Lijuan, et al.
Publicado: (2016)

Transcriptome profiling in preadipocytes identifies long noncoding RNAs as Sam68 targets
por: Li, Naomi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qpln50rdk3aef30rg7t78dpquh