Overexpressed Na(V)1.7 Channels Confer Hyperexcitability to in vitro Trigeminal Sensory Neurons of Ca(V)2.1 Mutant Hemiplegic Migraine Mice

Trigeminal sensory neurons of transgenic knock-in (KI) mice expressing the R192Q missense mutation in the α1A subunit of neuronal voltage-gated Ca(V)2.1 Ca(2+) channels, which leads to familial hemiplegic migraine type 1 (FHM1) in patients, exhibit a hyperexcitability phenotype. Here, we show that t...

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Detalles Bibliográficos
Autores principales: Mehboob, Riffat, Marchenkova, Anna, van den Maagdenberg, Arn M. J. M., Nistri, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185157/
https://www.ncbi.nlm.nih.gov/pubmed/34113237
http://dx.doi.org/10.3389/fncel.2021.640709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185157/
https://www.ncbi.nlm.nih.gov/pubmed/34113237
http://dx.doi.org/10.3389/fncel.2021.640709

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