Cargando…

Overexpressed Na(V)1.7 Channels Confer Hyperexcitability to in vitro Trigeminal Sensory Neurons of Ca(V)2.1 Mutant Hemiplegic Migraine Mice

Trigeminal sensory neurons of transgenic knock-in (KI) mice expressing the R192Q missense mutation in the α1A subunit of neuronal voltage-gated Ca(V)2.1 Ca(2+) channels, which leads to familial hemiplegic migraine type 1 (FHM1) in patients, exhibit a hyperexcitability phenotype. Here, we show that t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mehboob, Riffat, Marchenkova, Anna, van den Maagdenberg, Arn M. J. M., Nistri, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185157/ https://www.ncbi.nlm.nih.gov/pubmed/34113237 http://dx.doi.org/10.3389/fncel.2021.640709

Ejemplares similares

Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine
por: Marchenkova, Anna, et al.
Publicado: (2016)

Deciphering in silico the Role of Mutated Na(V)1.1 Sodium Channels in Enhancing Trigeminal Nociception in Familial Hemiplegic Migraine Type 3
por: Suleimanova, Alina, et al.
Publicado: (2021)

The Mechanism of Functional Up-Regulation of P2X3 Receptors of Trigeminal Sensory Neurons in a Genetic Mouse Model of Familial Hemiplegic Migraine Type 1 (FHM-1)
por: Hullugundi, Swathi K., et al.
Publicado: (2013)

Familial hemiplegic migraine Ca(V)2.1 channel mutation R192Q enhances ATP-gated P2X(3 )receptor activity of mouse sensory ganglion neurons mediating trigeminal pain
por: Nair, Asha, et al.
Publicado: (2010)

TNFα Levels and Macrophages Expression Reflect an Inflammatory Potential of Trigeminal Ganglia in a Mouse Model of Familial Hemiplegic Migraine
por: Franceschini, Alessia, et al.
Publicado: (2013)

Functional crosstalk in culture between macrophages and trigeminal sensory neurons of a mouse genetic model of migraine
por: Franceschini, Alessia, et al.
Publicado: (2012)

Lipid rafts control P2X3 receptor distribution and function in trigeminal sensory neurons of a transgenic migraine mouse model
por: Gnanasekaran, Aswini, et al.
Publicado: (2011)

Mutated Ca(V)2.1 channels dysregulate CASK/P2X3 signaling in mouse trigeminal sensory neurons of R192Q Cacna1a knock-in mice
por: Gnanasekaran, Aswini, et al.
Publicado: (2013)

B-Type Natriuretic Peptide-Induced Delayed Modulation of TRPV1 and P2X3 Receptors of Mouse Trigeminal Sensory Neurons
por: Vilotti, Sandra, et al.
Publicado: (2013)

Abnormal cortical synaptic transmission in Ca(V)2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans
por: Vecchia, Dania, et al.
Publicado: (2015)

Novel SCN1A mutation in the IFMT motif of the α1 subunit of the voltage-gated NaV1.1 channel causing familial hemiplegic migraine
por: De Vries, B, et al.
Publicado: (2013)

Editorial: Common and distinct mechanisms of migraine and stroke
por: Giniatullin, Rashid, et al.
Publicado: (2023)

Modeling Na(V)1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine
por: Lemaire, Louisiane, et al.
Publicado: (2021)

Ca(V)2.1 channel mutations causing familial hemiplegic migraine type 1 increase the susceptibility for cortical spreading depolarizations and seizures and worsen outcome after experimental traumatic brain injury
por: Terpolilli, Nicole A, et al.
Publicado: (2022)

Responsivity to light in familial hemiplegic migraine type 1 mutant mice reveals frequency‐dependent enhancement of visual network excitability
por: Perenboom, Matthijs J. L., et al.
Publicado: (2020)

Optogenetic cortical spreading depolarization induces headache-related behaviour and neuroinflammatory responses some prolonged in familial hemiplegic migraine type 1 mice
por: Dehghani, Anisa, et al.
Publicado: (2023)

Substance P/Neurokinin 1 and Trigeminal System: A Possible Link to the Pathogenesis in Sudden Perinatal Deaths
por: Mehboob, Riffat
Publicado: (2017)

Functional Connectivity Between the Trigeminal Main Sensory Nucleus and the Trigeminal Motor Nucleus
por: Slaoui Hasnaoui, Mohammed, et al.
Publicado: (2020)

Gain of Function for the SCN1A/hNa(v)1.1-L1670W Mutation Responsible for Familial Hemiplegic Migraine
por: Dhifallah, Sandra, et al.
Publicado: (2018)

Changes in Plasma Lipid Levels Following Cortical Spreading Depolarization in a Transgenic Mouse Model of Familial Hemiplegic Migraine
por: Loonen, Inge C. M., et al.
Publicado: (2022)

Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes
por: Maksemous, Neven, et al.
Publicado: (2023)

Sporadic Hemiplegic Migraine
por: Kana, Tina, et al.
Publicado: (2023)

Focal and generalized seizure activity after local hippocampal or cortical ablation of Na(V)1.1 channels in mice
por: Jansen, Nico A., et al.
Publicado: (2020)

Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in Ca(V)2.1 knockin migraine mice
por: Vecchia, Dania, et al.
Publicado: (2014)

Sex Differences in Hemostatic Factors in Patients With Ischemic Stroke and the Relation With Migraine—A Systematic Review
por: van der Weerd, Nelleke, et al.
Publicado: (2021)

Cerebellar Atrophy and Changes in Cytokines Associated with the CACNA1A R583Q Mutation in a Russian Familial Hemiplegic Migraine Type 1 Family
por: Khaiboullina, Svetlana F., et al.
Publicado: (2017)

Hemiplegic Migraine in Children and Adolescents
por: Bonemazzi, Ilaria, et al.
Publicado: (2023)

Paradoxical hyperexcitability from Na(V)1.2 sodium channel loss in neocortical pyramidal cells
por: Spratt, Perry W.E., et al.
Publicado: (2021)

Corticosterone enhances CSD susceptibility via glucocorticoid receptor activation in familial hemiplegic migraine 1 Cacna1a knock-in mice
por: Shyti, R, et al.
Publicado: (2013)

Sporadic hemiplegic migraine and CREST syndrome
por: Grecco, Martin Pablo, et al.
Publicado: (2010)

Neuropsychologic phenotypes in familial hemiplegic migraine
por: Roccella, Michele
Publicado: (2003)

Familial Hemiplegic Migraine and Spreading Depression
por: KAZEMI, Hadi, et al.
Publicado: (2014)

Diagnostic and therapeutic aspects of hemiplegic migraine
por: Di Stefano, Vincenzo, et al.
Publicado: (2020)

Biphasic voltage‐dependent inactivation of human Na(V)1.3, 1.6 and 1.7 Na(+) channels expressed in rodent insulin‐secreting cells
por: Godazgar, Mahdieh, et al.
Publicado: (2018)

The Nature of Noradrenergic Volume Transmission From Locus Coeruleus to Brainstem Mesencephalic Trigeminal Sensory Neurons
por: Toyoda, Hiroki, et al.
Publicado: (2022)

EHMTI-0262. Dysregulation of inflammatory pathways in a familial hemiplegic migraine 1 mouse model after the induction of cortical spreading depression
por: de Vries, B, et al.
Publicado: (2014)

Advance in genetics of migraine
por: de Boer, Irene, et al.
Publicado: (2019)

Mouse Models of Familial Hemiplegic Migraine for Studying Migraine Pathophysiology
por: Dehghani, Anisa, et al.
Publicado: (2019)

Genetics of migraine aura: an update
por: de Boer, Irene, et al.
Publicado: (2020)

Migraine and neuroinflammation: the inflammasome perspective
por: Kursun, Oguzhan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6utf66c4dlib5sjgul9vg71aqs