A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications

Faced with the challenges posed by infectious diseases and cancer, nucleic acid vaccines present excellent prospects in clinical applications. Compared with traditional vaccines, nucleic acid vaccines have the characteristics of high efficiency and low cost. Therefore, nucleic acid vaccines have pot...

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Detalles Bibliográficos
Autores principales: Qin, Furong, Xia, Fan, Chen, Hongli, Cui, Bomiao, Feng, Yun, Zhang, Ping, Chen, Jiao, Luo, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185206/
https://www.ncbi.nlm.nih.gov/pubmed/34113610
http://dx.doi.org/10.3389/fcell.2021.633776
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author Qin, Furong
Xia, Fan
Chen, Hongli
Cui, Bomiao
Feng, Yun
Zhang, Ping
Chen, Jiao
Luo, Min
author_facet Qin, Furong
Xia, Fan
Chen, Hongli
Cui, Bomiao
Feng, Yun
Zhang, Ping
Chen, Jiao
Luo, Min
author_sort Qin, Furong
collection PubMed
description Faced with the challenges posed by infectious diseases and cancer, nucleic acid vaccines present excellent prospects in clinical applications. Compared with traditional vaccines, nucleic acid vaccines have the characteristics of high efficiency and low cost. Therefore, nucleic acid vaccines have potential advantages in disease prevention and treatment. However, the low immunogenicity and instability of nucleic acid vaccines have limited their development. Therefore, a large number of studies have been conducted to improve their immunogenicity and stability by improving delivery methods, thereby supporting progress and development for clinical applications. This article mainly reviews the advantages, disadvantages, mechanisms, delivery methods, and clinical applications of nucleic acid vaccines.
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spelling pubmed-81852062021-06-09 A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications Qin, Furong Xia, Fan Chen, Hongli Cui, Bomiao Feng, Yun Zhang, Ping Chen, Jiao Luo, Min Front Cell Dev Biol Cell and Developmental Biology Faced with the challenges posed by infectious diseases and cancer, nucleic acid vaccines present excellent prospects in clinical applications. Compared with traditional vaccines, nucleic acid vaccines have the characteristics of high efficiency and low cost. Therefore, nucleic acid vaccines have potential advantages in disease prevention and treatment. However, the low immunogenicity and instability of nucleic acid vaccines have limited their development. Therefore, a large number of studies have been conducted to improve their immunogenicity and stability by improving delivery methods, thereby supporting progress and development for clinical applications. This article mainly reviews the advantages, disadvantages, mechanisms, delivery methods, and clinical applications of nucleic acid vaccines. Frontiers Media S.A. 2021-05-25 /pmc/articles/PMC8185206/ /pubmed/34113610 http://dx.doi.org/10.3389/fcell.2021.633776 Text en Copyright © 2021 Qin, Xia, Chen, Cui, Feng, Zhang, Chen and Luo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Qin, Furong
Xia, Fan
Chen, Hongli
Cui, Bomiao
Feng, Yun
Zhang, Ping
Chen, Jiao
Luo, Min
A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications
title A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications
title_full A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications
title_fullStr A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications
title_full_unstemmed A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications
title_short A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications
title_sort guide to nucleic acid vaccines in the prevention and treatment of infectious diseases and cancers: from basic principles to current applications
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185206/
https://www.ncbi.nlm.nih.gov/pubmed/34113610
http://dx.doi.org/10.3389/fcell.2021.633776
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