Low miR-214-5p Expression Correlates With Aggressive Subtypes of Pediatric ALCL With Non-Common Histology

The unsatisfactory cure rate of relapsing ALK-positive Anaplastic Large-Cell Lymphoma (ALCL) of childhood calls for the identification of new prognostic markers. Here, the small RNA landscape of pediatric ALK-positive ALCL was defined by RNA sequencing. Overall, 121 miRNAs were significantly dysregu...

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Detalles Bibliográficos
Autores principales: Di Battista, Piero, Lovisa, Federica, Gaffo, Enrico, Gallingani, Ilaria, Damanti, Carlotta C., Garbin, Anna, Ferrone, Lavinia, Carraro, Elisa, Pillon, Marta, Lo Nigro, Luca, Mura, Rossella, Pizzi, Marco, Guzzardo, Vincenza, Dei Tos, Angelo Paolo, Biffi, Alessandra, Bortoluzzi, Stefania, Mussolin, Lara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185221/
https://www.ncbi.nlm.nih.gov/pubmed/34113568
http://dx.doi.org/10.3389/fonc.2021.663221
Descripción
Sumario:The unsatisfactory cure rate of relapsing ALK-positive Anaplastic Large-Cell Lymphoma (ALCL) of childhood calls for the identification of new prognostic markers. Here, the small RNA landscape of pediatric ALK-positive ALCL was defined by RNA sequencing. Overall, 121 miRNAs were significantly dysregulated in ALCL compared to non-neoplastic lymph nodes. The most up-regulated miRNA was miR-21-5p, whereas miR-19a-3p and miR-214-5p were reduced in ALCL. Characterization of miRNA expression in cases that relapsed after first line therapy disclosed a significant association between miR-214-5p down-regulation and aggressive non-common histology. Our results suggest that miR-214-5p level may help to refine the prognostic stratification of pediatric ALK-positive ALCL.

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