Low miR-214-5p Expression Correlates With Aggressive Subtypes of Pediatric ALCL With Non-Common Histology

The unsatisfactory cure rate of relapsing ALK-positive Anaplastic Large-Cell Lymphoma (ALCL) of childhood calls for the identification of new prognostic markers. Here, the small RNA landscape of pediatric ALK-positive ALCL was defined by RNA sequencing. Overall, 121 miRNAs were significantly dysregu...

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Autores principales: Di Battista, Piero, Lovisa, Federica, Gaffo, Enrico, Gallingani, Ilaria, Damanti, Carlotta C., Garbin, Anna, Ferrone, Lavinia, Carraro, Elisa, Pillon, Marta, Lo Nigro, Luca, Mura, Rossella, Pizzi, Marco, Guzzardo, Vincenza, Dei Tos, Angelo Paolo, Biffi, Alessandra, Bortoluzzi, Stefania, Mussolin, Lara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185221/
https://www.ncbi.nlm.nih.gov/pubmed/34113568
http://dx.doi.org/10.3389/fonc.2021.663221
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author Di Battista, Piero
Lovisa, Federica
Gaffo, Enrico
Gallingani, Ilaria
Damanti, Carlotta C.
Garbin, Anna
Ferrone, Lavinia
Carraro, Elisa
Pillon, Marta
Lo Nigro, Luca
Mura, Rossella
Pizzi, Marco
Guzzardo, Vincenza
Dei Tos, Angelo Paolo
Biffi, Alessandra
Bortoluzzi, Stefania
Mussolin, Lara
author_facet Di Battista, Piero
Lovisa, Federica
Gaffo, Enrico
Gallingani, Ilaria
Damanti, Carlotta C.
Garbin, Anna
Ferrone, Lavinia
Carraro, Elisa
Pillon, Marta
Lo Nigro, Luca
Mura, Rossella
Pizzi, Marco
Guzzardo, Vincenza
Dei Tos, Angelo Paolo
Biffi, Alessandra
Bortoluzzi, Stefania
Mussolin, Lara
author_sort Di Battista, Piero
collection PubMed
description The unsatisfactory cure rate of relapsing ALK-positive Anaplastic Large-Cell Lymphoma (ALCL) of childhood calls for the identification of new prognostic markers. Here, the small RNA landscape of pediatric ALK-positive ALCL was defined by RNA sequencing. Overall, 121 miRNAs were significantly dysregulated in ALCL compared to non-neoplastic lymph nodes. The most up-regulated miRNA was miR-21-5p, whereas miR-19a-3p and miR-214-5p were reduced in ALCL. Characterization of miRNA expression in cases that relapsed after first line therapy disclosed a significant association between miR-214-5p down-regulation and aggressive non-common histology. Our results suggest that miR-214-5p level may help to refine the prognostic stratification of pediatric ALK-positive ALCL.
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spelling pubmed-81852212021-06-09 Low miR-214-5p Expression Correlates With Aggressive Subtypes of Pediatric ALCL With Non-Common Histology Di Battista, Piero Lovisa, Federica Gaffo, Enrico Gallingani, Ilaria Damanti, Carlotta C. Garbin, Anna Ferrone, Lavinia Carraro, Elisa Pillon, Marta Lo Nigro, Luca Mura, Rossella Pizzi, Marco Guzzardo, Vincenza Dei Tos, Angelo Paolo Biffi, Alessandra Bortoluzzi, Stefania Mussolin, Lara Front Oncol Oncology The unsatisfactory cure rate of relapsing ALK-positive Anaplastic Large-Cell Lymphoma (ALCL) of childhood calls for the identification of new prognostic markers. Here, the small RNA landscape of pediatric ALK-positive ALCL was defined by RNA sequencing. Overall, 121 miRNAs were significantly dysregulated in ALCL compared to non-neoplastic lymph nodes. The most up-regulated miRNA was miR-21-5p, whereas miR-19a-3p and miR-214-5p were reduced in ALCL. Characterization of miRNA expression in cases that relapsed after first line therapy disclosed a significant association between miR-214-5p down-regulation and aggressive non-common histology. Our results suggest that miR-214-5p level may help to refine the prognostic stratification of pediatric ALK-positive ALCL. Frontiers Media S.A. 2021-05-25 /pmc/articles/PMC8185221/ /pubmed/34113568 http://dx.doi.org/10.3389/fonc.2021.663221 Text en Copyright © 2021 Di Battista, Lovisa, Gaffo, Gallingani, Damanti, Garbin, Ferrone, Carraro, Pillon, Lo Nigro, Mura, Pizzi, Guzzardo, Dei Tos, Biffi, Bortoluzzi and Mussolin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Di Battista, Piero
Lovisa, Federica
Gaffo, Enrico
Gallingani, Ilaria
Damanti, Carlotta C.
Garbin, Anna
Ferrone, Lavinia
Carraro, Elisa
Pillon, Marta
Lo Nigro, Luca
Mura, Rossella
Pizzi, Marco
Guzzardo, Vincenza
Dei Tos, Angelo Paolo
Biffi, Alessandra
Bortoluzzi, Stefania
Mussolin, Lara
Low miR-214-5p Expression Correlates With Aggressive Subtypes of Pediatric ALCL With Non-Common Histology
title Low miR-214-5p Expression Correlates With Aggressive Subtypes of Pediatric ALCL With Non-Common Histology
title_full Low miR-214-5p Expression Correlates With Aggressive Subtypes of Pediatric ALCL With Non-Common Histology
title_fullStr Low miR-214-5p Expression Correlates With Aggressive Subtypes of Pediatric ALCL With Non-Common Histology
title_full_unstemmed Low miR-214-5p Expression Correlates With Aggressive Subtypes of Pediatric ALCL With Non-Common Histology
title_short Low miR-214-5p Expression Correlates With Aggressive Subtypes of Pediatric ALCL With Non-Common Histology
title_sort low mir-214-5p expression correlates with aggressive subtypes of pediatric alcl with non-common histology
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185221/
https://www.ncbi.nlm.nih.gov/pubmed/34113568
http://dx.doi.org/10.3389/fonc.2021.663221
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