RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence

Recent data suggest that therapy-resistant quiescent cancer stem cells (qCSCs) are the source of relapse in colon cancer. Here, using colon cancer patient-derived organoids and xenografts, we identify rare long-term label-retaining qCSCs that can re-enter the cell cycle to generate new tumors. RNA s...

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Detalles Bibliográficos
Autores principales: Regan, Joseph L., Schumacher, Dirk, Staudte, Stephanie, Steffen, Andreas, Lesche, Ralf, Toedling, Joern, Jourdan, Thibaud, Haybaeck, Johannes, Mumberg, Dominik, Henderson, David, Győrffy, Balázs, Regenbrecht, Christian R.A., Keilholz, Ulrich, Schäfer, Reinhold, Lange, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185225/
https://www.ncbi.nlm.nih.gov/pubmed/34142064
http://dx.doi.org/10.1016/j.isci.2021.102618

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