A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19

An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheo...

Descripción completa

Detalles Bibliográficos
Autores principales: Yeo, Joo Guan, Leong, Jing Yao, Tay, Shi Huan, Nadua, Karen Donceras, Anderson, Danielle E., Lim, Amanda Jin Mei, Ng, Xiang Wen, Poh, Su Li, Guo, Dianyan, Yaung, Katherine Nay, Kumar, Pavanish, Wasser, Martin, Hazirah, Sharifah Nur, Sutamam, Nursyuhadah, Chua, Camillus Jian Hui, Qui, Martin, Foo, Randy, Gamage, Akshamal Mihiranga, Yeo, Kee Thai, Ramakrishna, Lakshmi, Arkachaisri, Thaschawee, Young, Barnaby E., Lye, David Chien, Wang, Lin-Fa, Chong, Chia Yin, Tan, Natalie Woon Hui, Li, Jiahui, Kam, Kai-Qian, Ginhoux, Florent, Thoon, Koh Cheng, Chan, Jerry Kok Yen, Yung, Chee Fu, Albani, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185226/
https://www.ncbi.nlm.nih.gov/pubmed/34113347
http://dx.doi.org/10.3389/fimmu.2021.674279
Descripción
Sumario:An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheostat composed of an effector T (T(eff)) cell recall response that is balanced by the enrichment of a highly specialized regulatory T (T(reg)) cell subset. Both components were reactive against a peptide pool covering the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. We also observed expansion of IFNγ(+) memory CD4(+) T cells and virus-specific follicular helper T (T(FH)) cells. Overall, these findings pinpoint critical immune effector and regulatory mechanisms essential for a potent, yet harmless resolution of COVID-19 infection.

Ejemplares similares