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A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19
An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheo...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185226/ https://www.ncbi.nlm.nih.gov/pubmed/34113347 http://dx.doi.org/10.3389/fimmu.2021.674279 |
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| author | Yeo, Joo Guan Leong, Jing Yao Tay, Shi Huan Nadua, Karen Donceras Anderson, Danielle E. Lim, Amanda Jin Mei Ng, Xiang Wen Poh, Su Li Guo, Dianyan Yaung, Katherine Nay Kumar, Pavanish Wasser, Martin Hazirah, Sharifah Nur Sutamam, Nursyuhadah Chua, Camillus Jian Hui Qui, Martin Foo, Randy Gamage, Akshamal Mihiranga Yeo, Kee Thai Ramakrishna, Lakshmi Arkachaisri, Thaschawee Young, Barnaby E. Lye, David Chien Wang, Lin-Fa Chong, Chia Yin Tan, Natalie Woon Hui Li, Jiahui Kam, Kai-Qian Ginhoux, Florent Thoon, Koh Cheng Chan, Jerry Kok Yen Yung, Chee Fu Albani, Salvatore |
| author_facet | Yeo, Joo Guan Leong, Jing Yao Tay, Shi Huan Nadua, Karen Donceras Anderson, Danielle E. Lim, Amanda Jin Mei Ng, Xiang Wen Poh, Su Li Guo, Dianyan Yaung, Katherine Nay Kumar, Pavanish Wasser, Martin Hazirah, Sharifah Nur Sutamam, Nursyuhadah Chua, Camillus Jian Hui Qui, Martin Foo, Randy Gamage, Akshamal Mihiranga Yeo, Kee Thai Ramakrishna, Lakshmi Arkachaisri, Thaschawee Young, Barnaby E. Lye, David Chien Wang, Lin-Fa Chong, Chia Yin Tan, Natalie Woon Hui Li, Jiahui Kam, Kai-Qian Ginhoux, Florent Thoon, Koh Cheng Chan, Jerry Kok Yen Yung, Chee Fu Albani, Salvatore |
| author_sort | Yeo, Joo Guan |
| collection | PubMed |
| description | An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheostat composed of an effector T (T(eff)) cell recall response that is balanced by the enrichment of a highly specialized regulatory T (T(reg)) cell subset. Both components were reactive against a peptide pool covering the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. We also observed expansion of IFNγ(+) memory CD4(+) T cells and virus-specific follicular helper T (T(FH)) cells. Overall, these findings pinpoint critical immune effector and regulatory mechanisms essential for a potent, yet harmless resolution of COVID-19 infection. |
| format | Online Article Text |
| id | pubmed-8185226 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-81852262021-06-09 A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19 Yeo, Joo Guan Leong, Jing Yao Tay, Shi Huan Nadua, Karen Donceras Anderson, Danielle E. Lim, Amanda Jin Mei Ng, Xiang Wen Poh, Su Li Guo, Dianyan Yaung, Katherine Nay Kumar, Pavanish Wasser, Martin Hazirah, Sharifah Nur Sutamam, Nursyuhadah Chua, Camillus Jian Hui Qui, Martin Foo, Randy Gamage, Akshamal Mihiranga Yeo, Kee Thai Ramakrishna, Lakshmi Arkachaisri, Thaschawee Young, Barnaby E. Lye, David Chien Wang, Lin-Fa Chong, Chia Yin Tan, Natalie Woon Hui Li, Jiahui Kam, Kai-Qian Ginhoux, Florent Thoon, Koh Cheng Chan, Jerry Kok Yen Yung, Chee Fu Albani, Salvatore Front Immunol Immunology An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheostat composed of an effector T (T(eff)) cell recall response that is balanced by the enrichment of a highly specialized regulatory T (T(reg)) cell subset. Both components were reactive against a peptide pool covering the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. We also observed expansion of IFNγ(+) memory CD4(+) T cells and virus-specific follicular helper T (T(FH)) cells. Overall, these findings pinpoint critical immune effector and regulatory mechanisms essential for a potent, yet harmless resolution of COVID-19 infection. Frontiers Media S.A. 2021-05-25 /pmc/articles/PMC8185226/ /pubmed/34113347 http://dx.doi.org/10.3389/fimmu.2021.674279 Text en Copyright © 2021 Yeo, Leong, Tay, Nadua, Anderson, Lim, Ng, Poh, Guo, Yaung, Kumar, Wasser, Hazirah, Sutamam, Chua, Qui, Foo, Gamage, Yeo, Ramakrishna, Arkachaisri, Young, Lye, Wang, Chong, Tan, Li, Kam, Ginhoux, Thoon, Chan, Yung and Albani https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Immunology Yeo, Joo Guan Leong, Jing Yao Tay, Shi Huan Nadua, Karen Donceras Anderson, Danielle E. Lim, Amanda Jin Mei Ng, Xiang Wen Poh, Su Li Guo, Dianyan Yaung, Katherine Nay Kumar, Pavanish Wasser, Martin Hazirah, Sharifah Nur Sutamam, Nursyuhadah Chua, Camillus Jian Hui Qui, Martin Foo, Randy Gamage, Akshamal Mihiranga Yeo, Kee Thai Ramakrishna, Lakshmi Arkachaisri, Thaschawee Young, Barnaby E. Lye, David Chien Wang, Lin-Fa Chong, Chia Yin Tan, Natalie Woon Hui Li, Jiahui Kam, Kai-Qian Ginhoux, Florent Thoon, Koh Cheng Chan, Jerry Kok Yen Yung, Chee Fu Albani, Salvatore A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19 |
| title | A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19 |
| title_full | A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19 |
| title_fullStr | A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19 |
| title_full_unstemmed | A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19 |
| title_short | A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19 |
| title_sort | virus-specific immune rheostat in the immunome of patients recovering from mild covid-19 |
| topic | Immunology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185226/ https://www.ncbi.nlm.nih.gov/pubmed/34113347 http://dx.doi.org/10.3389/fimmu.2021.674279 |
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