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Could vagus nerve stimulation influence bone remodeling?

OBJECTIVES: To investigate the effect of vagus nerve stimulation (VNS) on the bone mineral density (BMD) in epileptic patients. METHODS: A prospective cohort study was conducted on individuals with refractory seizures who underwent VNS surgery between January 2012 and December 2018. BMD was measured...

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Autores principales: Tamimi, Ahmad, Tamimi, Faleh, Juweid, Malik, Al-Qudah, Abdelkarim A., Masri, Amira Al, Dahbour, Said, Bahou, Yakub Al, Shareef, Abdelatif, Tamimi, Iskandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Society of Musculoskeletal and Neuronal Interactions 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185259/
https://www.ncbi.nlm.nih.gov/pubmed/34059570
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author Tamimi, Ahmad
Tamimi, Faleh
Juweid, Malik
Al-Qudah, Abdelkarim A.
Masri, Amira Al
Dahbour, Said
Bahou, Yakub Al
Shareef, Abdelatif
Tamimi, Iskandar
author_facet Tamimi, Ahmad
Tamimi, Faleh
Juweid, Malik
Al-Qudah, Abdelkarim A.
Masri, Amira Al
Dahbour, Said
Bahou, Yakub Al
Shareef, Abdelatif
Tamimi, Iskandar
author_sort Tamimi, Ahmad
collection PubMed
description OBJECTIVES: To investigate the effect of vagus nerve stimulation (VNS) on the bone mineral density (BMD) in epileptic patients. METHODS: A prospective cohort study was conducted on individuals with refractory seizures who underwent VNS surgery between January 2012 and December 2018. BMD was measured preoperatively and between 6 months and one year after surgery. RESULTS: Twenty-one patients (mean age (±SD)=23.6±12.3 years) were recruited for the implantation of a VNS device. The mean absolute increase in lumbar BMD in the 21 patients was 0.04±0.04 g/cm(2) resulting in an overall percent increase from baseline of 4.7±6.1%. BMD increased by an amount ≥ the least significant change (LSC) for the lumbar spine in 13 patients (61.9%). The lumbar Z score also increased in these patients from -1.22±1.15 to -0.88±1.22, P=0.006). Pre and Post VNA femoral BMD was measured in only 11 patients and, of those 3 showed a significant increase in BMD, 1 a significant decrease and 7 no change. CONCLUSION: The implantation of a VNS was associated with an increase in lumbar BMD. This study could lead to a new application for VNS in the treatment of osteoporosis.
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spelling pubmed-81852592021-06-10 Could vagus nerve stimulation influence bone remodeling? Tamimi, Ahmad Tamimi, Faleh Juweid, Malik Al-Qudah, Abdelkarim A. Masri, Amira Al Dahbour, Said Bahou, Yakub Al Shareef, Abdelatif Tamimi, Iskandar J Musculoskelet Neuronal Interact Original Article OBJECTIVES: To investigate the effect of vagus nerve stimulation (VNS) on the bone mineral density (BMD) in epileptic patients. METHODS: A prospective cohort study was conducted on individuals with refractory seizures who underwent VNS surgery between January 2012 and December 2018. BMD was measured preoperatively and between 6 months and one year after surgery. RESULTS: Twenty-one patients (mean age (±SD)=23.6±12.3 years) were recruited for the implantation of a VNS device. The mean absolute increase in lumbar BMD in the 21 patients was 0.04±0.04 g/cm(2) resulting in an overall percent increase from baseline of 4.7±6.1%. BMD increased by an amount ≥ the least significant change (LSC) for the lumbar spine in 13 patients (61.9%). The lumbar Z score also increased in these patients from -1.22±1.15 to -0.88±1.22, P=0.006). Pre and Post VNA femoral BMD was measured in only 11 patients and, of those 3 showed a significant increase in BMD, 1 a significant decrease and 7 no change. CONCLUSION: The implantation of a VNS was associated with an increase in lumbar BMD. This study could lead to a new application for VNS in the treatment of osteoporosis. International Society of Musculoskeletal and Neuronal Interactions 2021 /pmc/articles/PMC8185259/ /pubmed/34059570 Text en Copyright: © Journal of Musculoskeletal and Neuronal Interactions https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Tamimi, Ahmad
Tamimi, Faleh
Juweid, Malik
Al-Qudah, Abdelkarim A.
Masri, Amira Al
Dahbour, Said
Bahou, Yakub Al
Shareef, Abdelatif
Tamimi, Iskandar
Could vagus nerve stimulation influence bone remodeling?
title Could vagus nerve stimulation influence bone remodeling?
title_full Could vagus nerve stimulation influence bone remodeling?
title_fullStr Could vagus nerve stimulation influence bone remodeling?
title_full_unstemmed Could vagus nerve stimulation influence bone remodeling?
title_short Could vagus nerve stimulation influence bone remodeling?
title_sort could vagus nerve stimulation influence bone remodeling?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185259/
https://www.ncbi.nlm.nih.gov/pubmed/34059570
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