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Study on Omentin-1 and miR-502-3p in osteoporotic fracture

OBJECTIVES: To explore the expression and correlation of Omentin-1 and miR-502-3p in serum of patients with osteoporotic fracture (OPF). METHODS: Sixty OPF patients diagnosed and treated in our hospital from June 2018 to December 2019 were included in group A. Fifty-six osteoporosis patients without...

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Autores principales: Zhang, Jing, Hou, Yun, Wang, Zhaoli, Zhou, Peng, Zhang, Ping, Wang, Jixian, Sun, Zhengang, Wang, Liyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Society of Musculoskeletal and Neuronal Interactions 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185270/
https://www.ncbi.nlm.nih.gov/pubmed/34059576
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author Zhang, Jing
Hou, Yun
Wang, Zhaoli
Zhou, Peng
Zhang, Ping
Wang, Jixian
Sun, Zhengang
Wang, Liyun
author_facet Zhang, Jing
Hou, Yun
Wang, Zhaoli
Zhou, Peng
Zhang, Ping
Wang, Jixian
Sun, Zhengang
Wang, Liyun
author_sort Zhang, Jing
collection PubMed
description OBJECTIVES: To explore the expression and correlation of Omentin-1 and miR-502-3p in serum of patients with osteoporotic fracture (OPF). METHODS: Sixty OPF patients diagnosed and treated in our hospital from June 2018 to December 2019 were included in group A. Fifty-six osteoporosis patients without fractures were included in group B. Omentin-1 and miR-502-3p levels were detected by enzyme-linked immunosorbent assay (ELISA) and real-time quantitative PCR (qRT-PCR). Their predictive value for diagnostic efficiency was assessed by ROC curve. Spearman’s rank correlation test was used for correlation analysis. The risk factors related to the prognosis of OPF were analyzed by Logistic univariate and multivariate analysis. RESULTS: The expression of Omentin-1 and miR-502-3p in group A was markedly lower than in group B (P<0.001). Spearman correlation analysis showed that in OPF, there was a negative correlation between serum Omentin-1 and TNF-α (r=0.8579, P<0.001), a negative correlation between serum miR-502-3p and TNF-α (r= 0.8653, P<0.001), and a positive correlation between serum Omentin-1 and miR-502-3p (r= 0.8764, P<0.001). CONCLUSIONS: Omentin-1 and miR-502-3p were down-regulated in serum of patients with OPF, both of which could be used as potential biomarkers for the diagnosis and disease evaluation of OPF.
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spelling pubmed-81852702021-06-10 Study on Omentin-1 and miR-502-3p in osteoporotic fracture Zhang, Jing Hou, Yun Wang, Zhaoli Zhou, Peng Zhang, Ping Wang, Jixian Sun, Zhengang Wang, Liyun J Musculoskelet Neuronal Interact Original Article OBJECTIVES: To explore the expression and correlation of Omentin-1 and miR-502-3p in serum of patients with osteoporotic fracture (OPF). METHODS: Sixty OPF patients diagnosed and treated in our hospital from June 2018 to December 2019 were included in group A. Fifty-six osteoporosis patients without fractures were included in group B. Omentin-1 and miR-502-3p levels were detected by enzyme-linked immunosorbent assay (ELISA) and real-time quantitative PCR (qRT-PCR). Their predictive value for diagnostic efficiency was assessed by ROC curve. Spearman’s rank correlation test was used for correlation analysis. The risk factors related to the prognosis of OPF were analyzed by Logistic univariate and multivariate analysis. RESULTS: The expression of Omentin-1 and miR-502-3p in group A was markedly lower than in group B (P<0.001). Spearman correlation analysis showed that in OPF, there was a negative correlation between serum Omentin-1 and TNF-α (r=0.8579, P<0.001), a negative correlation between serum miR-502-3p and TNF-α (r= 0.8653, P<0.001), and a positive correlation between serum Omentin-1 and miR-502-3p (r= 0.8764, P<0.001). CONCLUSIONS: Omentin-1 and miR-502-3p were down-regulated in serum of patients with OPF, both of which could be used as potential biomarkers for the diagnosis and disease evaluation of OPF. International Society of Musculoskeletal and Neuronal Interactions 2021 /pmc/articles/PMC8185270/ /pubmed/34059576 Text en Copyright: © Journal of Musculoskeletal and Neuronal Interactions https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Zhang, Jing
Hou, Yun
Wang, Zhaoli
Zhou, Peng
Zhang, Ping
Wang, Jixian
Sun, Zhengang
Wang, Liyun
Study on Omentin-1 and miR-502-3p in osteoporotic fracture
title Study on Omentin-1 and miR-502-3p in osteoporotic fracture
title_full Study on Omentin-1 and miR-502-3p in osteoporotic fracture
title_fullStr Study on Omentin-1 and miR-502-3p in osteoporotic fracture
title_full_unstemmed Study on Omentin-1 and miR-502-3p in osteoporotic fracture
title_short Study on Omentin-1 and miR-502-3p in osteoporotic fracture
title_sort study on omentin-1 and mir-502-3p in osteoporotic fracture
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185270/
https://www.ncbi.nlm.nih.gov/pubmed/34059576
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