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The Prognostic Value of the Acute Phase Systemic Immune–Inflammation Index in Patients With Intracerebral Hemorrhage

Background and Purpose: The systemic immune–inflammation index (SII) is a novel prognostic index in various diseases. We evaluated the predictive value of SII in patients with intracerebral hemorrhage (ICH). Methods: Patients with primary spontaneous ICH were enrolled. SII was constructed based on p...

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Autores principales: Li, Yunke, Wen, Dingke, Cui, Wenyao, Chen, Yuqi, Zhang, Fazhen, Yuan, Maolin, Xiao, Han, Li, Hao, Ma, Lu, Hu, Xin, You, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185273/
https://www.ncbi.nlm.nih.gov/pubmed/34113303
http://dx.doi.org/10.3389/fneur.2021.628557
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author Li, Yunke
Wen, Dingke
Cui, Wenyao
Chen, Yuqi
Zhang, Fazhen
Yuan, Maolin
Xiao, Han
Li, Hao
Ma, Lu
Hu, Xin
You, Chao
author_facet Li, Yunke
Wen, Dingke
Cui, Wenyao
Chen, Yuqi
Zhang, Fazhen
Yuan, Maolin
Xiao, Han
Li, Hao
Ma, Lu
Hu, Xin
You, Chao
author_sort Li, Yunke
collection PubMed
description Background and Purpose: The systemic immune–inflammation index (SII) is a novel prognostic index in various diseases. We evaluated the predictive value of SII in patients with intracerebral hemorrhage (ICH). Methods: Patients with primary spontaneous ICH were enrolled. SII was constructed based on peripheral platelet (P), neutrophil (N), and lymphocyte (L) and defined as P(*)N/L. In addition to admission testing, acute phase SII was collected to analyze the potential dynamic change. Poor outcome was defined as modified Rankin Scale of more than 3 at 90 days. Results: We included 291 patients; 98 (34%) achieved favorable functional outcomes. Day-1 SII was higher and was more related to poor outcome than was admission SII. Median time of day-1 SII was 29 h from onset. Day-1 SII had an OR in outcome (mRS >3) 1.74 (95% CI = 1.03–3.00, p = 0.04). The binary cutoff point of SII calculated using the area under the curve (AUC) method was 1,700 × 10(9)/L, AUC 0.699 (95% CI = 0.627–0.774) (sensitivity 53.3%, specificity 77.3%) (OR = 2.36, 95% CI = 1.09–5.26, p = 0.03). Conclusions: SII, especially day-1 SII, was highly associated with 90-day functional outcome in patients with ICH and could be used to predict outcomes.
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spelling pubmed-81852732021-06-09 The Prognostic Value of the Acute Phase Systemic Immune–Inflammation Index in Patients With Intracerebral Hemorrhage Li, Yunke Wen, Dingke Cui, Wenyao Chen, Yuqi Zhang, Fazhen Yuan, Maolin Xiao, Han Li, Hao Ma, Lu Hu, Xin You, Chao Front Neurol Neurology Background and Purpose: The systemic immune–inflammation index (SII) is a novel prognostic index in various diseases. We evaluated the predictive value of SII in patients with intracerebral hemorrhage (ICH). Methods: Patients with primary spontaneous ICH were enrolled. SII was constructed based on peripheral platelet (P), neutrophil (N), and lymphocyte (L) and defined as P(*)N/L. In addition to admission testing, acute phase SII was collected to analyze the potential dynamic change. Poor outcome was defined as modified Rankin Scale of more than 3 at 90 days. Results: We included 291 patients; 98 (34%) achieved favorable functional outcomes. Day-1 SII was higher and was more related to poor outcome than was admission SII. Median time of day-1 SII was 29 h from onset. Day-1 SII had an OR in outcome (mRS >3) 1.74 (95% CI = 1.03–3.00, p = 0.04). The binary cutoff point of SII calculated using the area under the curve (AUC) method was 1,700 × 10(9)/L, AUC 0.699 (95% CI = 0.627–0.774) (sensitivity 53.3%, specificity 77.3%) (OR = 2.36, 95% CI = 1.09–5.26, p = 0.03). Conclusions: SII, especially day-1 SII, was highly associated with 90-day functional outcome in patients with ICH and could be used to predict outcomes. Frontiers Media S.A. 2021-05-25 /pmc/articles/PMC8185273/ /pubmed/34113303 http://dx.doi.org/10.3389/fneur.2021.628557 Text en Copyright © 2021 Li, Wen, Cui, Chen, Zhang, Yuan, Xiao, Li, Ma, Hu and You. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Li, Yunke
Wen, Dingke
Cui, Wenyao
Chen, Yuqi
Zhang, Fazhen
Yuan, Maolin
Xiao, Han
Li, Hao
Ma, Lu
Hu, Xin
You, Chao
The Prognostic Value of the Acute Phase Systemic Immune–Inflammation Index in Patients With Intracerebral Hemorrhage
title The Prognostic Value of the Acute Phase Systemic Immune–Inflammation Index in Patients With Intracerebral Hemorrhage
title_full The Prognostic Value of the Acute Phase Systemic Immune–Inflammation Index in Patients With Intracerebral Hemorrhage
title_fullStr The Prognostic Value of the Acute Phase Systemic Immune–Inflammation Index in Patients With Intracerebral Hemorrhage
title_full_unstemmed The Prognostic Value of the Acute Phase Systemic Immune–Inflammation Index in Patients With Intracerebral Hemorrhage
title_short The Prognostic Value of the Acute Phase Systemic Immune–Inflammation Index in Patients With Intracerebral Hemorrhage
title_sort prognostic value of the acute phase systemic immune–inflammation index in patients with intracerebral hemorrhage
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185273/
https://www.ncbi.nlm.nih.gov/pubmed/34113303
http://dx.doi.org/10.3389/fneur.2021.628557
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