The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease

Brown adipose tissue (BAT), consisted of brown adipocytes and stromal vascular fraction, which includes endothelial cells, lymphocytes, fibroblasts and stem cells, plays a vital role in regulating cardiovascular health and diseases. As a thermogenic organ, BAT can influence body through strengthenin...

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Autores principales: Chen, Hong-Jin, Meng, Ting, Gao, Ping-Jin, Ruan, Cheng-Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185286/
https://www.ncbi.nlm.nih.gov/pubmed/34113316
http://dx.doi.org/10.3389/fendo.2021.652246
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author Chen, Hong-Jin
Meng, Ting
Gao, Ping-Jin
Ruan, Cheng-Chao
author_facet Chen, Hong-Jin
Meng, Ting
Gao, Ping-Jin
Ruan, Cheng-Chao
author_sort Chen, Hong-Jin
collection PubMed
description Brown adipose tissue (BAT), consisted of brown adipocytes and stromal vascular fraction, which includes endothelial cells, lymphocytes, fibroblasts and stem cells, plays a vital role in regulating cardiovascular health and diseases. As a thermogenic organ, BAT can influence body through strengthening energy expenditure by promoting glucose and lipid metabolism. In addition, BAT is also an endocrine organ which is able to secret adipokines in an autocrine and/or paracrine fashion. BAT plays a protective role in cardiovascular system through attenuating cardiac remodeling and suppressing inflammatory response. In this review, we summarize the advances from the discovery of BAT to the present and provide an overview on the role of BAT dysfunction in cardiovascular diseases.
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spelling pubmed-81852862021-06-09 The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease Chen, Hong-Jin Meng, Ting Gao, Ping-Jin Ruan, Cheng-Chao Front Endocrinol (Lausanne) Endocrinology Brown adipose tissue (BAT), consisted of brown adipocytes and stromal vascular fraction, which includes endothelial cells, lymphocytes, fibroblasts and stem cells, plays a vital role in regulating cardiovascular health and diseases. As a thermogenic organ, BAT can influence body through strengthening energy expenditure by promoting glucose and lipid metabolism. In addition, BAT is also an endocrine organ which is able to secret adipokines in an autocrine and/or paracrine fashion. BAT plays a protective role in cardiovascular system through attenuating cardiac remodeling and suppressing inflammatory response. In this review, we summarize the advances from the discovery of BAT to the present and provide an overview on the role of BAT dysfunction in cardiovascular diseases. Frontiers Media S.A. 2021-05-25 /pmc/articles/PMC8185286/ /pubmed/34113316 http://dx.doi.org/10.3389/fendo.2021.652246 Text en Copyright © 2021 Chen, Meng, Gao and Ruan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Chen, Hong-Jin
Meng, Ting
Gao, Ping-Jin
Ruan, Cheng-Chao
The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease
title The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease
title_full The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease
title_fullStr The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease
title_full_unstemmed The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease
title_short The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease
title_sort role of brown adipose tissue dysfunction in the development of cardiovascular disease
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185286/
https://www.ncbi.nlm.nih.gov/pubmed/34113316
http://dx.doi.org/10.3389/fendo.2021.652246
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