Cargando…

Archaea: A Gold Mine for Topoisomerase Diversity

The control of DNA topology is a prerequisite for all the DNA transactions such as DNA replication, repair, recombination, and transcription. This global control is carried out by essential enzymes, named DNA-topoisomerases, that are mandatory for the genome stability. Since many decades, the Archae...

Descripción completa

Detalles Bibliográficos
Autores principales: Garnier, Florence, Couturier, Mohea, Débat, Hélène, Nadal, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185306/
https://www.ncbi.nlm.nih.gov/pubmed/34113328
http://dx.doi.org/10.3389/fmicb.2021.661411
_version_ 1783704762721501184
author Garnier, Florence
Couturier, Mohea
Débat, Hélène
Nadal, Marc
author_facet Garnier, Florence
Couturier, Mohea
Débat, Hélène
Nadal, Marc
author_sort Garnier, Florence
collection PubMed
description The control of DNA topology is a prerequisite for all the DNA transactions such as DNA replication, repair, recombination, and transcription. This global control is carried out by essential enzymes, named DNA-topoisomerases, that are mandatory for the genome stability. Since many decades, the Archaea provide a significant panel of new types of topoisomerases such as the reverse gyrase, the type IIB or the type IC. These more or less recent discoveries largely contributed to change the understanding of the role of the DNA topoisomerases in all the living world. Despite their very different life styles, Archaea share a quasi-homogeneous set of DNA-topoisomerases, except thermophilic organisms that possess at least one reverse gyrase that is considered a marker of the thermophily. Here, we discuss the effect of the life style of Archaea on DNA structure and topology and then we review the content of these essential enzymes within all the archaeal diversity based on complete sequenced genomes available. Finally, we discuss their roles, in particular in the processes involved in both the archaeal adaptation and the preservation of the genome stability.
format Online
Article
Text
id pubmed-8185306
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81853062021-06-09 Archaea: A Gold Mine for Topoisomerase Diversity Garnier, Florence Couturier, Mohea Débat, Hélène Nadal, Marc Front Microbiol Microbiology The control of DNA topology is a prerequisite for all the DNA transactions such as DNA replication, repair, recombination, and transcription. This global control is carried out by essential enzymes, named DNA-topoisomerases, that are mandatory for the genome stability. Since many decades, the Archaea provide a significant panel of new types of topoisomerases such as the reverse gyrase, the type IIB or the type IC. These more or less recent discoveries largely contributed to change the understanding of the role of the DNA topoisomerases in all the living world. Despite their very different life styles, Archaea share a quasi-homogeneous set of DNA-topoisomerases, except thermophilic organisms that possess at least one reverse gyrase that is considered a marker of the thermophily. Here, we discuss the effect of the life style of Archaea on DNA structure and topology and then we review the content of these essential enzymes within all the archaeal diversity based on complete sequenced genomes available. Finally, we discuss their roles, in particular in the processes involved in both the archaeal adaptation and the preservation of the genome stability. Frontiers Media S.A. 2021-05-25 /pmc/articles/PMC8185306/ /pubmed/34113328 http://dx.doi.org/10.3389/fmicb.2021.661411 Text en Copyright © 2021 Garnier, Couturier, Débat and Nadal. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Garnier, Florence
Couturier, Mohea
Débat, Hélène
Nadal, Marc
Archaea: A Gold Mine for Topoisomerase Diversity
title Archaea: A Gold Mine for Topoisomerase Diversity
title_full Archaea: A Gold Mine for Topoisomerase Diversity
title_fullStr Archaea: A Gold Mine for Topoisomerase Diversity
title_full_unstemmed Archaea: A Gold Mine for Topoisomerase Diversity
title_short Archaea: A Gold Mine for Topoisomerase Diversity
title_sort archaea: a gold mine for topoisomerase diversity
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185306/
https://www.ncbi.nlm.nih.gov/pubmed/34113328
http://dx.doi.org/10.3389/fmicb.2021.661411
work_keys_str_mv AT garnierflorence archaeaagoldminefortopoisomerasediversity
AT couturiermohea archaeaagoldminefortopoisomerasediversity
AT debathelene archaeaagoldminefortopoisomerasediversity
AT nadalmarc archaeaagoldminefortopoisomerasediversity