Characterization of Human CD4 T Cells Specific for a C-Peptide/C-Peptide Hybrid Insulin Peptide

Hybrid Insulin Peptides (HIPs), which consist of insulin fragments fused to other peptides from β-cell secretory granule proteins, are CD4 T cell autoantigens in type 1 diabetes (T1D). We have studied HIPs and HIP-reactive CD4 T cells extensively in the context of the non-obese diabetic (NOD) mouse...

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Detalles Bibliográficos
Autores principales: Wiles, Timothy A., Hohenstein, Anita, Landry, Laurie G., Dang, Mylinh, Powell, Roger, Guyer, Perrin, James, Eddie A., Nakayama, Maki, Haskins, Kathryn, Delong, Thomas, Baker, Rocky L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185328/
https://www.ncbi.nlm.nih.gov/pubmed/34113344
http://dx.doi.org/10.3389/fimmu.2021.668680

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