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Luminescent AIE Dots for Anticancer Photodynamic Therapy

Photodynamic therapy (PDT) is an emerging effective strategy for cancer treatment. Compared with conventional cancer therapies, such as surgery, chemotherapy, and radiotherapy, PDT has shown great promise as a next-generation cancer therapeutic strategy owing to its many advantages such as non-invas...

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Autores principales: He, Zhenyan, Tian, Sidan, Gao, Yuting, Meng, Fanling, Luo, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185329/
https://www.ncbi.nlm.nih.gov/pubmed/34113602
http://dx.doi.org/10.3389/fchem.2021.672917
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author He, Zhenyan
Tian, Sidan
Gao, Yuting
Meng, Fanling
Luo, Liang
author_facet He, Zhenyan
Tian, Sidan
Gao, Yuting
Meng, Fanling
Luo, Liang
author_sort He, Zhenyan
collection PubMed
description Photodynamic therapy (PDT) is an emerging effective strategy for cancer treatment. Compared with conventional cancer therapies, such as surgery, chemotherapy, and radiotherapy, PDT has shown great promise as a next-generation cancer therapeutic strategy owing to its many advantages such as non-invasiveness, negligible observed drug resistance, localized treatment, and fewer side effects. One of the key elements in photodynamic therapy is the photosensitizer (PS) which converts photons into active cytotoxic species, namely, reactive oxygen species (ROS). An ideal PS for photodynamic therapy requires the efficient generation of ROS, high stability against photo bleaching, and robust performance in different environments and concentrations. PSs with aggregation-induced emission (AIE) characteristics have drawn significant attention, in that they can overcome the aggregation- caused quenching effect that is commonly seen in the case of fluorescence dyes and provide excellent performance at high concentrations or in their condensed state. Moreover, organic nanomaterials with AIE characteristics, or AIE dots, have played an increasingly significant role in assisting PDT based on its excellent ROS generation efficiency and simultaneous imaging feature. This review summarizes the recent advances on the molecular design of AIE PSs and AIE dots-based probes, as well as their emerging applications for enhanced anticancer PDT theranostics.
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spelling pubmed-81853292021-06-09 Luminescent AIE Dots for Anticancer Photodynamic Therapy He, Zhenyan Tian, Sidan Gao, Yuting Meng, Fanling Luo, Liang Front Chem Chemistry Photodynamic therapy (PDT) is an emerging effective strategy for cancer treatment. Compared with conventional cancer therapies, such as surgery, chemotherapy, and radiotherapy, PDT has shown great promise as a next-generation cancer therapeutic strategy owing to its many advantages such as non-invasiveness, negligible observed drug resistance, localized treatment, and fewer side effects. One of the key elements in photodynamic therapy is the photosensitizer (PS) which converts photons into active cytotoxic species, namely, reactive oxygen species (ROS). An ideal PS for photodynamic therapy requires the efficient generation of ROS, high stability against photo bleaching, and robust performance in different environments and concentrations. PSs with aggregation-induced emission (AIE) characteristics have drawn significant attention, in that they can overcome the aggregation- caused quenching effect that is commonly seen in the case of fluorescence dyes and provide excellent performance at high concentrations or in their condensed state. Moreover, organic nanomaterials with AIE characteristics, or AIE dots, have played an increasingly significant role in assisting PDT based on its excellent ROS generation efficiency and simultaneous imaging feature. This review summarizes the recent advances on the molecular design of AIE PSs and AIE dots-based probes, as well as their emerging applications for enhanced anticancer PDT theranostics. Frontiers Media S.A. 2021-05-25 /pmc/articles/PMC8185329/ /pubmed/34113602 http://dx.doi.org/10.3389/fchem.2021.672917 Text en Copyright © 2021 He, Tian, Gao, Meng and Luo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
He, Zhenyan
Tian, Sidan
Gao, Yuting
Meng, Fanling
Luo, Liang
Luminescent AIE Dots for Anticancer Photodynamic Therapy
title Luminescent AIE Dots for Anticancer Photodynamic Therapy
title_full Luminescent AIE Dots for Anticancer Photodynamic Therapy
title_fullStr Luminescent AIE Dots for Anticancer Photodynamic Therapy
title_full_unstemmed Luminescent AIE Dots for Anticancer Photodynamic Therapy
title_short Luminescent AIE Dots for Anticancer Photodynamic Therapy
title_sort luminescent aie dots for anticancer photodynamic therapy
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185329/
https://www.ncbi.nlm.nih.gov/pubmed/34113602
http://dx.doi.org/10.3389/fchem.2021.672917
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