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Biomechanical Glaucoma Factor and Corneal Hysteresis in Treated Primary Open-Angle Glaucoma and Their Associations With Visual Field Progression

PURPOSE: To investigate the relationship between biomechanical glaucoma factor (BGF) measured with Corvis ST and glaucomatous visual field (VF) progression, compared to corneal hysteresis (CH) measured with ocular response analyzer using a longitudinal dataset of primary open-angle glaucoma (POAG)....

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Autores principales: Aoki, Shuichiro, Miki, Atsuya, Omoto, Takashi, Fujino, Yuri, Matsuura, Masato, Murata, Hiroshi, Asaoka, Ryo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185393/
https://www.ncbi.nlm.nih.gov/pubmed/34086046
http://dx.doi.org/10.1167/iovs.62.7.4
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author Aoki, Shuichiro
Miki, Atsuya
Omoto, Takashi
Fujino, Yuri
Matsuura, Masato
Murata, Hiroshi
Asaoka, Ryo
author_facet Aoki, Shuichiro
Miki, Atsuya
Omoto, Takashi
Fujino, Yuri
Matsuura, Masato
Murata, Hiroshi
Asaoka, Ryo
author_sort Aoki, Shuichiro
collection PubMed
description PURPOSE: To investigate the relationship between biomechanical glaucoma factor (BGF) measured with Corvis ST and glaucomatous visual field (VF) progression, compared to corneal hysteresis (CH) measured with ocular response analyzer using a longitudinal dataset of primary open-angle glaucoma (POAG). The discriminative powers of BGF and CH were also compared using a cross-sectional dataset. METHODS: The longitudinal dataset included 166 POAG eyes. The rate of VF change during the follow-up period was evaluated using the mean of 52 pointwise total deviations in the Humphrey 24-2 field test. Variables associated with the VF progression rate were identified from BGF, CH, age, baseline VF severity, and intraocular pressure during the VF follow-up period by identifying the optimal model. The cross-sectional dataset included 68 POAG eyes and 68 healthy eyes. Using this dataset, the area under the curve (AUC) values of the receiver-operating curve were compared between CH and BGF. RESULTS: The optimal multivariate linear mixed model to describe the VF rate included age and CH, but not BGF. Between POAG and healthy eyes, CH was statistically different (P < 0.001), although this was not the case with BGF. The AUC values were 0.61 and 0.71 for BGF and CH, respectively (P = 0.027). CONCLUSIONS: CH, but not BGF, was associated with VF progression in POAG patients under treatment. BGF was not useful to discriminate POAG between treated and normal eyes.
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spelling pubmed-81853932021-06-16 Biomechanical Glaucoma Factor and Corneal Hysteresis in Treated Primary Open-Angle Glaucoma and Their Associations With Visual Field Progression Aoki, Shuichiro Miki, Atsuya Omoto, Takashi Fujino, Yuri Matsuura, Masato Murata, Hiroshi Asaoka, Ryo Invest Ophthalmol Vis Sci Glaucoma PURPOSE: To investigate the relationship between biomechanical glaucoma factor (BGF) measured with Corvis ST and glaucomatous visual field (VF) progression, compared to corneal hysteresis (CH) measured with ocular response analyzer using a longitudinal dataset of primary open-angle glaucoma (POAG). The discriminative powers of BGF and CH were also compared using a cross-sectional dataset. METHODS: The longitudinal dataset included 166 POAG eyes. The rate of VF change during the follow-up period was evaluated using the mean of 52 pointwise total deviations in the Humphrey 24-2 field test. Variables associated with the VF progression rate were identified from BGF, CH, age, baseline VF severity, and intraocular pressure during the VF follow-up period by identifying the optimal model. The cross-sectional dataset included 68 POAG eyes and 68 healthy eyes. Using this dataset, the area under the curve (AUC) values of the receiver-operating curve were compared between CH and BGF. RESULTS: The optimal multivariate linear mixed model to describe the VF rate included age and CH, but not BGF. Between POAG and healthy eyes, CH was statistically different (P < 0.001), although this was not the case with BGF. The AUC values were 0.61 and 0.71 for BGF and CH, respectively (P = 0.027). CONCLUSIONS: CH, but not BGF, was associated with VF progression in POAG patients under treatment. BGF was not useful to discriminate POAG between treated and normal eyes. The Association for Research in Vision and Ophthalmology 2021-06-04 /pmc/articles/PMC8185393/ /pubmed/34086046 http://dx.doi.org/10.1167/iovs.62.7.4 Text en Copyright 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Glaucoma
Aoki, Shuichiro
Miki, Atsuya
Omoto, Takashi
Fujino, Yuri
Matsuura, Masato
Murata, Hiroshi
Asaoka, Ryo
Biomechanical Glaucoma Factor and Corneal Hysteresis in Treated Primary Open-Angle Glaucoma and Their Associations With Visual Field Progression
title Biomechanical Glaucoma Factor and Corneal Hysteresis in Treated Primary Open-Angle Glaucoma and Their Associations With Visual Field Progression
title_full Biomechanical Glaucoma Factor and Corneal Hysteresis in Treated Primary Open-Angle Glaucoma and Their Associations With Visual Field Progression
title_fullStr Biomechanical Glaucoma Factor and Corneal Hysteresis in Treated Primary Open-Angle Glaucoma and Their Associations With Visual Field Progression
title_full_unstemmed Biomechanical Glaucoma Factor and Corneal Hysteresis in Treated Primary Open-Angle Glaucoma and Their Associations With Visual Field Progression
title_short Biomechanical Glaucoma Factor and Corneal Hysteresis in Treated Primary Open-Angle Glaucoma and Their Associations With Visual Field Progression
title_sort biomechanical glaucoma factor and corneal hysteresis in treated primary open-angle glaucoma and their associations with visual field progression
topic Glaucoma
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185393/
https://www.ncbi.nlm.nih.gov/pubmed/34086046
http://dx.doi.org/10.1167/iovs.62.7.4
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