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Self-organized signaling in stem cell models of embryos
Mammalian embryonic development is a complex process driven by self-organization. Understanding how a fertilized egg develops into an embryo composed of more than 200 cell types in precise spatial patterns remains one of the fundamental challenges in biology. Pluripotent stem cells have been used as...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185436/ https://www.ncbi.nlm.nih.gov/pubmed/33979594 http://dx.doi.org/10.1016/j.stemcr.2021.03.020 |
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author | Liu, Lizhong Warmflash, Aryeh |
author_facet | Liu, Lizhong Warmflash, Aryeh |
author_sort | Liu, Lizhong |
collection | PubMed |
description | Mammalian embryonic development is a complex process driven by self-organization. Understanding how a fertilized egg develops into an embryo composed of more than 200 cell types in precise spatial patterns remains one of the fundamental challenges in biology. Pluripotent stem cells have been used as in vitro models for investigating mammalian development, and represent promising building blocks for regenerative therapies. Recently, sophisticated stem cell-based models that recapitulate early embryonic fate patterning and morphogenesis have been developed. In this article, we review recent advances in stem cell models of embryos in particular focusing on signaling activities underpinning cell fate decisions in space and time. |
format | Online Article Text |
id | pubmed-8185436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-81854362021-06-16 Self-organized signaling in stem cell models of embryos Liu, Lizhong Warmflash, Aryeh Stem Cell Reports Review Mammalian embryonic development is a complex process driven by self-organization. Understanding how a fertilized egg develops into an embryo composed of more than 200 cell types in precise spatial patterns remains one of the fundamental challenges in biology. Pluripotent stem cells have been used as in vitro models for investigating mammalian development, and represent promising building blocks for regenerative therapies. Recently, sophisticated stem cell-based models that recapitulate early embryonic fate patterning and morphogenesis have been developed. In this article, we review recent advances in stem cell models of embryos in particular focusing on signaling activities underpinning cell fate decisions in space and time. Elsevier 2021-05-11 /pmc/articles/PMC8185436/ /pubmed/33979594 http://dx.doi.org/10.1016/j.stemcr.2021.03.020 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Liu, Lizhong Warmflash, Aryeh Self-organized signaling in stem cell models of embryos |
title | Self-organized signaling in stem cell models of embryos |
title_full | Self-organized signaling in stem cell models of embryos |
title_fullStr | Self-organized signaling in stem cell models of embryos |
title_full_unstemmed | Self-organized signaling in stem cell models of embryos |
title_short | Self-organized signaling in stem cell models of embryos |
title_sort | self-organized signaling in stem cell models of embryos |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185436/ https://www.ncbi.nlm.nih.gov/pubmed/33979594 http://dx.doi.org/10.1016/j.stemcr.2021.03.020 |
work_keys_str_mv | AT liulizhong selforganizedsignalinginstemcellmodelsofembryos AT warmflasharyeh selforganizedsignalinginstemcellmodelsofembryos |