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Self-organized signaling in stem cell models of embryos

Mammalian embryonic development is a complex process driven by self-organization. Understanding how a fertilized egg develops into an embryo composed of more than 200 cell types in precise spatial patterns remains one of the fundamental challenges in biology. Pluripotent stem cells have been used as...

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Detalles Bibliográficos
Autores principales: Liu, Lizhong, Warmflash, Aryeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185436/
https://www.ncbi.nlm.nih.gov/pubmed/33979594
http://dx.doi.org/10.1016/j.stemcr.2021.03.020
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author Liu, Lizhong
Warmflash, Aryeh
author_facet Liu, Lizhong
Warmflash, Aryeh
author_sort Liu, Lizhong
collection PubMed
description Mammalian embryonic development is a complex process driven by self-organization. Understanding how a fertilized egg develops into an embryo composed of more than 200 cell types in precise spatial patterns remains one of the fundamental challenges in biology. Pluripotent stem cells have been used as in vitro models for investigating mammalian development, and represent promising building blocks for regenerative therapies. Recently, sophisticated stem cell-based models that recapitulate early embryonic fate patterning and morphogenesis have been developed. In this article, we review recent advances in stem cell models of embryos in particular focusing on signaling activities underpinning cell fate decisions in space and time.
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spelling pubmed-81854362021-06-16 Self-organized signaling in stem cell models of embryos Liu, Lizhong Warmflash, Aryeh Stem Cell Reports Review Mammalian embryonic development is a complex process driven by self-organization. Understanding how a fertilized egg develops into an embryo composed of more than 200 cell types in precise spatial patterns remains one of the fundamental challenges in biology. Pluripotent stem cells have been used as in vitro models for investigating mammalian development, and represent promising building blocks for regenerative therapies. Recently, sophisticated stem cell-based models that recapitulate early embryonic fate patterning and morphogenesis have been developed. In this article, we review recent advances in stem cell models of embryos in particular focusing on signaling activities underpinning cell fate decisions in space and time. Elsevier 2021-05-11 /pmc/articles/PMC8185436/ /pubmed/33979594 http://dx.doi.org/10.1016/j.stemcr.2021.03.020 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Liu, Lizhong
Warmflash, Aryeh
Self-organized signaling in stem cell models of embryos
title Self-organized signaling in stem cell models of embryos
title_full Self-organized signaling in stem cell models of embryos
title_fullStr Self-organized signaling in stem cell models of embryos
title_full_unstemmed Self-organized signaling in stem cell models of embryos
title_short Self-organized signaling in stem cell models of embryos
title_sort self-organized signaling in stem cell models of embryos
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185436/
https://www.ncbi.nlm.nih.gov/pubmed/33979594
http://dx.doi.org/10.1016/j.stemcr.2021.03.020
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