Systemic Sarcoidosis Induced by Chemotherapy, Mimicking Metastatic Testicular Carcinoma with (18)F-FDG PET/CT

A 34-year-old male patient who had left orchiectomy and received three cycles of chemotherapy for testicular mix germ cell carcinoma was referred for (18)fluorine-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for complaints of weight loss and fever. PET/CT...

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Autores principales: Arslan, Esra, Aksoy, Tamer, Ekemen, Süheyla, Çermik, Tevfik Fikret
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185480/
https://www.ncbi.nlm.nih.gov/pubmed/34082518
http://dx.doi.org/10.4274/mirt.galenos.2020.51422
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author Arslan, Esra
Aksoy, Tamer
Ekemen, Süheyla
Çermik, Tevfik Fikret
author_facet Arslan, Esra
Aksoy, Tamer
Ekemen, Süheyla
Çermik, Tevfik Fikret
author_sort Arslan, Esra
collection PubMed
description A 34-year-old male patient who had left orchiectomy and received three cycles of chemotherapy for testicular mix germ cell carcinoma was referred for (18)fluorine-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for complaints of weight loss and fever. PET/CT showed multiple and progressive (18)F-FDG uptakes in supra and infra diaphragmatic lymphatic regions, and multiple abnormal (18)F-FDG uptakes were noted in the lytic formed skeletal lesions. Clinicians remain in doubt regarding the multiple metastatic lesions without elevated serum tumor marker levels (alpha-fetoprotein, beta-human chorionic gonadotrophin, CA19-9, and carcinoembryonic antigen). Biopsy of the lytic lesion in the iliac bone revealed granulomatous inflammation suggestive of sarcoidosis. Systemic prednisone at 20-40 mg/daily was started. (18)F-FDG PET/CT images showed complete metabolic response to prednisone 8 months following the start of treatment.
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spelling pubmed-81854802021-06-17 Systemic Sarcoidosis Induced by Chemotherapy, Mimicking Metastatic Testicular Carcinoma with (18)F-FDG PET/CT Arslan, Esra Aksoy, Tamer Ekemen, Süheyla Çermik, Tevfik Fikret Mol Imaging Radionucl Ther Interesting Image A 34-year-old male patient who had left orchiectomy and received three cycles of chemotherapy for testicular mix germ cell carcinoma was referred for (18)fluorine-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for complaints of weight loss and fever. PET/CT showed multiple and progressive (18)F-FDG uptakes in supra and infra diaphragmatic lymphatic regions, and multiple abnormal (18)F-FDG uptakes were noted in the lytic formed skeletal lesions. Clinicians remain in doubt regarding the multiple metastatic lesions without elevated serum tumor marker levels (alpha-fetoprotein, beta-human chorionic gonadotrophin, CA19-9, and carcinoembryonic antigen). Biopsy of the lytic lesion in the iliac bone revealed granulomatous inflammation suggestive of sarcoidosis. Systemic prednisone at 20-40 mg/daily was started. (18)F-FDG PET/CT images showed complete metabolic response to prednisone 8 months following the start of treatment. Galenos Publishing 2021-06 2021-06-03 /pmc/articles/PMC8185480/ /pubmed/34082518 http://dx.doi.org/10.4274/mirt.galenos.2020.51422 Text en ©Copyright 2021 by Turkish Society of Nuclear Medicine | Molecular Imaging and Radionuclide Therapy published by Galenos Yayınevi. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Interesting Image
Arslan, Esra
Aksoy, Tamer
Ekemen, Süheyla
Çermik, Tevfik Fikret
Systemic Sarcoidosis Induced by Chemotherapy, Mimicking Metastatic Testicular Carcinoma with (18)F-FDG PET/CT
title Systemic Sarcoidosis Induced by Chemotherapy, Mimicking Metastatic Testicular Carcinoma with (18)F-FDG PET/CT
title_full Systemic Sarcoidosis Induced by Chemotherapy, Mimicking Metastatic Testicular Carcinoma with (18)F-FDG PET/CT
title_fullStr Systemic Sarcoidosis Induced by Chemotherapy, Mimicking Metastatic Testicular Carcinoma with (18)F-FDG PET/CT
title_full_unstemmed Systemic Sarcoidosis Induced by Chemotherapy, Mimicking Metastatic Testicular Carcinoma with (18)F-FDG PET/CT
title_short Systemic Sarcoidosis Induced by Chemotherapy, Mimicking Metastatic Testicular Carcinoma with (18)F-FDG PET/CT
title_sort systemic sarcoidosis induced by chemotherapy, mimicking metastatic testicular carcinoma with (18)f-fdg pet/ct
topic Interesting Image
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185480/
https://www.ncbi.nlm.nih.gov/pubmed/34082518
http://dx.doi.org/10.4274/mirt.galenos.2020.51422
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AT ekemensuheyla systemicsarcoidosisinducedbychemotherapymimickingmetastatictesticularcarcinomawith18ffdgpetct
AT cermiktevfikfikret systemicsarcoidosisinducedbychemotherapymimickingmetastatictesticularcarcinomawith18ffdgpetct

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