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High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts

Mutations in OPA1 cause autosomal dominant optic atrophy (DOA) as well as DOA+, a phenotype characterized by more severe neurological deficits. OPA1 deficiency causes mitochondrial fragmentation and also disrupts cristae, respiration, mitochondrial DNA (mtDNA) maintenance, and cell viability. It has...

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Detalles Bibliográficos
Autores principales:	Cretin, Emma, Lopes, Priscilla, Vimont, Elodie, Tatsuta, Takashi, Langer, Thomas, Gazi, Anastasia, Sachse, Martin, Yu‐Wai‐Man, Patrick, Reynier, Pascal, Wai, Timothy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185549/ https://www.ncbi.nlm.nih.gov/pubmed/34014035 http://dx.doi.org/10.15252/emmm.202013579

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