Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia

Most patients with pancreatic adenocarcinoma (PDAC) suffer cachexia; some do not. To model heterogeneity, we used patient-derived orthotopic xenografts. These phenocopied donor weight loss. Furthermore, muscle wasting correlated with mortality and murine IL-6, and human IL-6 associated with the grea...

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Detalles Bibliográficos
Autores principales: Rupert, Joseph E., Narasimhan, Ashok, Jengelley, Daenique H.A., Jiang, Yanlin, Liu, Jianguo, Au, Ernie, Silverman, Libbie M., Sandusky, George, Bonetto, Andrea, Cao, Sha, Lu, Xiaoyu, O’Connell, Thomas M., Liu, Yunlong, Koniaris, Leonidas G., Zimmers, Teresa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185651/
https://www.ncbi.nlm.nih.gov/pubmed/33851955
http://dx.doi.org/10.1084/jem.20190450

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