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Gold-based nanomaterials for the treatment of brain cancer
Brain cancer, also known as intracranial cancer, is one of the most invasive and fatal cancers affecting people of all ages. Despite the great advances in medical technology, improvements in transporting drugs into brain tissue have been limited by the challenge of crossing the blood-brain barrier (...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Compuscript
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185869/ https://www.ncbi.nlm.nih.gov/pubmed/34002583 http://dx.doi.org/10.20892/j.issn.2095-3941.2020.0524 |
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author | Tu, Li Luo, Zheng Wu, Yun-Long Huo, Shuaidong Liang, Xing-Jie |
author_facet | Tu, Li Luo, Zheng Wu, Yun-Long Huo, Shuaidong Liang, Xing-Jie |
author_sort | Tu, Li |
collection | PubMed |
description | Brain cancer, also known as intracranial cancer, is one of the most invasive and fatal cancers affecting people of all ages. Despite the great advances in medical technology, improvements in transporting drugs into brain tissue have been limited by the challenge of crossing the blood-brain barrier (BBB). Fortunately, recent endeavors using gold-based nanomaterials (GBNs) have indicated the potential of these materials to cross the BBB. Therefore, GBNs might be an attractive therapeutic strategy against brain cancer. Herein, we aim to present a comprehensive summary of current understanding of the critical effects of the physicochemical properties and surface modifications of GBNs on BBB penetration for applications in brain cancer treatment. Furthermore, the most recent GBNs and their impressive performance in precise bioimaging and efficient inhibition of brain tumors are also summarized, with an emphasis on the mechanism of their effective BBB penetration. Finally, the challenges and future outlook in using GBNs for brain cancer treatment are discussed. We hope that this review will spark researchers’ interest in constructing more powerful nanoplatforms for brain disease treatment. |
format | Online Article Text |
id | pubmed-8185869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Compuscript |
record_format | MEDLINE/PubMed |
spelling | pubmed-81858692021-06-25 Gold-based nanomaterials for the treatment of brain cancer Tu, Li Luo, Zheng Wu, Yun-Long Huo, Shuaidong Liang, Xing-Jie Cancer Biol Med Review Brain cancer, also known as intracranial cancer, is one of the most invasive and fatal cancers affecting people of all ages. Despite the great advances in medical technology, improvements in transporting drugs into brain tissue have been limited by the challenge of crossing the blood-brain barrier (BBB). Fortunately, recent endeavors using gold-based nanomaterials (GBNs) have indicated the potential of these materials to cross the BBB. Therefore, GBNs might be an attractive therapeutic strategy against brain cancer. Herein, we aim to present a comprehensive summary of current understanding of the critical effects of the physicochemical properties and surface modifications of GBNs on BBB penetration for applications in brain cancer treatment. Furthermore, the most recent GBNs and their impressive performance in precise bioimaging and efficient inhibition of brain tumors are also summarized, with an emphasis on the mechanism of their effective BBB penetration. Finally, the challenges and future outlook in using GBNs for brain cancer treatment are discussed. We hope that this review will spark researchers’ interest in constructing more powerful nanoplatforms for brain disease treatment. Compuscript 2021-05-15 2021-06-15 /pmc/articles/PMC8185869/ /pubmed/34002583 http://dx.doi.org/10.20892/j.issn.2095-3941.2020.0524 Text en Copyright: © 2021, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0 (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Tu, Li Luo, Zheng Wu, Yun-Long Huo, Shuaidong Liang, Xing-Jie Gold-based nanomaterials for the treatment of brain cancer |
title | Gold-based nanomaterials for the treatment of brain cancer |
title_full | Gold-based nanomaterials for the treatment of brain cancer |
title_fullStr | Gold-based nanomaterials for the treatment of brain cancer |
title_full_unstemmed | Gold-based nanomaterials for the treatment of brain cancer |
title_short | Gold-based nanomaterials for the treatment of brain cancer |
title_sort | gold-based nanomaterials for the treatment of brain cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185869/ https://www.ncbi.nlm.nih.gov/pubmed/34002583 http://dx.doi.org/10.20892/j.issn.2095-3941.2020.0524 |
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