In Parkinson's patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition

Pathophysiological changes in dopamine neurons precede their demise and contribute to the early phases of Parkinson’s disease (PD). Intracellular pathological inclusions of the protein α-synuclein within dopaminergic neurons are a cardinal feature of PD, but the mechanisms by which α-synuclein contr...

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Detalles Bibliográficos
Autores principales: Lin, Min, Mackie, Phillip M., Shaerzadeh, Fatima, Gamble-George, Joyonna, Miller, Douglas R., Martyniuk, Chris J., Khoshbouei, Habibeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185945/
https://www.ncbi.nlm.nih.gov/pubmed/34099060
http://dx.doi.org/10.1186/s40478-021-01203-9

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