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Primary diaphragmatic undifferentiated pleomorphic sarcoma in a cat

CASE SUMMARY: A 5-year-old neutered female domestic shorthair cat was referred for acute onset of dyspnoea. Thoracic radiographs performed by the referring veterinarian revealed the presence of pleural effusion. Upon presentation, the cat was dyspnoeic, and cardiopulmonary auscultation revealed muff...

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Autores principales: Bonazzi, Irene, Morabito, Simona, Brunetti, Barbara, Nicoli, Stefano, Valenti, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186119/
https://www.ncbi.nlm.nih.gov/pubmed/34158969
http://dx.doi.org/10.1177/20551169211018992
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author Bonazzi, Irene
Morabito, Simona
Brunetti, Barbara
Nicoli, Stefano
Valenti, Paola
author_facet Bonazzi, Irene
Morabito, Simona
Brunetti, Barbara
Nicoli, Stefano
Valenti, Paola
author_sort Bonazzi, Irene
collection PubMed
description CASE SUMMARY: A 5-year-old neutered female domestic shorthair cat was referred for acute onset of dyspnoea. Thoracic radiographs performed by the referring veterinarian revealed the presence of pleural effusion. Upon presentation, the cat was dyspnoeic, and cardiopulmonary auscultation revealed muffled heart sounds and bilaterally increased bronchovesicular sounds. Radiographic study of the thorax revealed bilateral pleural effusion and a soft tissue opacity in the dorsocaudal region of the left hemithorax. A whole-body contrast-enhanced CT scan identified a soft tissue mass arising from the left diaphragmatic crus. Transthoracic ultrasound-guided fine-needle aspiration (FNA) of the mass was performed and the result was consistent with a malignant mesenchymal neoplasia, showing giant cells. Cytoreductive surgery was performed and the histopathology diagnosis of undifferentiated pleomorphic sarcoma was made. Adjuvant chemotherapy was then offered. Ten days after surgery pleural effusion recurred. Thoracic echography revealed the presence of a diaphragmatic thickening in the area of surgical resection. FNA of the thickening was consistent with mesenchymal neoplasia. Even when chemotherapy and supportive treatment with pain relief was instituted, the clinical condition of the cat worsened within a few days and it was euthanased 1 month after surgery. RELEVANCE AND NOVEL INFORMATION: Primary diaphragmatic tumours (PDTs) have been rarely reported in human and in veterinary medicine, where only three cases have been described in the dog. To our knowledge, this is the first report to describe a PDT, specifically an undifferentiated pleomorphic sarcoma, in a cat.
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spelling pubmed-81861192021-06-21 Primary diaphragmatic undifferentiated pleomorphic sarcoma in a cat Bonazzi, Irene Morabito, Simona Brunetti, Barbara Nicoli, Stefano Valenti, Paola JFMS Open Rep Case Report CASE SUMMARY: A 5-year-old neutered female domestic shorthair cat was referred for acute onset of dyspnoea. Thoracic radiographs performed by the referring veterinarian revealed the presence of pleural effusion. Upon presentation, the cat was dyspnoeic, and cardiopulmonary auscultation revealed muffled heart sounds and bilaterally increased bronchovesicular sounds. Radiographic study of the thorax revealed bilateral pleural effusion and a soft tissue opacity in the dorsocaudal region of the left hemithorax. A whole-body contrast-enhanced CT scan identified a soft tissue mass arising from the left diaphragmatic crus. Transthoracic ultrasound-guided fine-needle aspiration (FNA) of the mass was performed and the result was consistent with a malignant mesenchymal neoplasia, showing giant cells. Cytoreductive surgery was performed and the histopathology diagnosis of undifferentiated pleomorphic sarcoma was made. Adjuvant chemotherapy was then offered. Ten days after surgery pleural effusion recurred. Thoracic echography revealed the presence of a diaphragmatic thickening in the area of surgical resection. FNA of the thickening was consistent with mesenchymal neoplasia. Even when chemotherapy and supportive treatment with pain relief was instituted, the clinical condition of the cat worsened within a few days and it was euthanased 1 month after surgery. RELEVANCE AND NOVEL INFORMATION: Primary diaphragmatic tumours (PDTs) have been rarely reported in human and in veterinary medicine, where only three cases have been described in the dog. To our knowledge, this is the first report to describe a PDT, specifically an undifferentiated pleomorphic sarcoma, in a cat. SAGE Publications 2021-05-31 /pmc/articles/PMC8186119/ /pubmed/34158969 http://dx.doi.org/10.1177/20551169211018992 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Bonazzi, Irene
Morabito, Simona
Brunetti, Barbara
Nicoli, Stefano
Valenti, Paola
Primary diaphragmatic undifferentiated pleomorphic sarcoma in a cat
title Primary diaphragmatic undifferentiated pleomorphic sarcoma in a cat
title_full Primary diaphragmatic undifferentiated pleomorphic sarcoma in a cat
title_fullStr Primary diaphragmatic undifferentiated pleomorphic sarcoma in a cat
title_full_unstemmed Primary diaphragmatic undifferentiated pleomorphic sarcoma in a cat
title_short Primary diaphragmatic undifferentiated pleomorphic sarcoma in a cat
title_sort primary diaphragmatic undifferentiated pleomorphic sarcoma in a cat
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186119/
https://www.ncbi.nlm.nih.gov/pubmed/34158969
http://dx.doi.org/10.1177/20551169211018992
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