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Correlations between apparent diffusion coefficient values of WB-DWI and clinical parameters in multiple myeloma
BACKGROUND: Whole-body diffusion-weighted imaging (WB-DWI) is a method for evaluating bone marrow infiltration in multiple myeloma (MM). This study seeks to elucidate the correlation between the apparent diffusion coefficient (ADC) value and some selected clinical parameters. METHODS: A total of 101...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186136/ https://www.ncbi.nlm.nih.gov/pubmed/34103001 http://dx.doi.org/10.1186/s12880-021-00631-2 |
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author | Zhang, Bei Bian, Bingyang Zhao, Zhiwei Lin, Fang Zhu, Zining Lou, Mingwu |
author_facet | Zhang, Bei Bian, Bingyang Zhao, Zhiwei Lin, Fang Zhu, Zining Lou, Mingwu |
author_sort | Zhang, Bei |
collection | PubMed |
description | BACKGROUND: Whole-body diffusion-weighted imaging (WB-DWI) is a method for evaluating bone marrow infiltration in multiple myeloma (MM). This study seeks to elucidate the correlation between the apparent diffusion coefficient (ADC) value and some selected clinical parameters. METHODS: A total of 101 Chinese patients with MM who had undergone WB-DWI from May 2017 to May 2019 were enrolled in this study. The ADC values of the MM lesions and the clinical parameters were quantified at the first (baseline) visit and after four-course induction chemotherapy. Multiple linear regression and logistic analyses were carried out to find the implicit inherent relationships within the patients’ data. RESULTS: The paired Wilcoxon test showed that the ADC values at the baseline visit (ADC(0)) were significantly lower than the values after four-course induction chemotherapy (ADC(4 c)) (p < 0.001), including different therapeutic responses. The Revised International Staging System (RISS) stage, type of MM, and β2-microglobulin (β2-MG) were predictors of clinically significant increases or decreases in the ADC values (p < 0.05). Multiple linear regression showed that the ADC(0) was negatively associated with β2-MG (p < 0.001) and immunoglobulin heavy chain gene rearrangement (p = 0.012), while the RISS Stage III (p = 0.001), type IgG λ (p = 0.005), and albumin were negatively associated with ADC(4 c) (p = 0.010). The impacts of the therapeutic response were associated with ADC(0) and immunoglobulin heavy chain gene rearrangement (p < 0.001). CONCLUSION: The ADC values of WB-DWI may be associated with clinical parameters of MM including the fluorescence in situ hybridization result, and may be useful in the prognosis of patients with MM. Trial Registration: ChiCTR2000029587 |
format | Online Article Text |
id | pubmed-8186136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-81861362021-06-10 Correlations between apparent diffusion coefficient values of WB-DWI and clinical parameters in multiple myeloma Zhang, Bei Bian, Bingyang Zhao, Zhiwei Lin, Fang Zhu, Zining Lou, Mingwu BMC Med Imaging Research Article BACKGROUND: Whole-body diffusion-weighted imaging (WB-DWI) is a method for evaluating bone marrow infiltration in multiple myeloma (MM). This study seeks to elucidate the correlation between the apparent diffusion coefficient (ADC) value and some selected clinical parameters. METHODS: A total of 101 Chinese patients with MM who had undergone WB-DWI from May 2017 to May 2019 were enrolled in this study. The ADC values of the MM lesions and the clinical parameters were quantified at the first (baseline) visit and after four-course induction chemotherapy. Multiple linear regression and logistic analyses were carried out to find the implicit inherent relationships within the patients’ data. RESULTS: The paired Wilcoxon test showed that the ADC values at the baseline visit (ADC(0)) were significantly lower than the values after four-course induction chemotherapy (ADC(4 c)) (p < 0.001), including different therapeutic responses. The Revised International Staging System (RISS) stage, type of MM, and β2-microglobulin (β2-MG) were predictors of clinically significant increases or decreases in the ADC values (p < 0.05). Multiple linear regression showed that the ADC(0) was negatively associated with β2-MG (p < 0.001) and immunoglobulin heavy chain gene rearrangement (p = 0.012), while the RISS Stage III (p = 0.001), type IgG λ (p = 0.005), and albumin were negatively associated with ADC(4 c) (p = 0.010). The impacts of the therapeutic response were associated with ADC(0) and immunoglobulin heavy chain gene rearrangement (p < 0.001). CONCLUSION: The ADC values of WB-DWI may be associated with clinical parameters of MM including the fluorescence in situ hybridization result, and may be useful in the prognosis of patients with MM. Trial Registration: ChiCTR2000029587 BioMed Central 2021-06-08 /pmc/articles/PMC8186136/ /pubmed/34103001 http://dx.doi.org/10.1186/s12880-021-00631-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Zhang, Bei Bian, Bingyang Zhao, Zhiwei Lin, Fang Zhu, Zining Lou, Mingwu Correlations between apparent diffusion coefficient values of WB-DWI and clinical parameters in multiple myeloma |
title | Correlations between apparent diffusion coefficient values of WB-DWI and clinical parameters in multiple myeloma |
title_full | Correlations between apparent diffusion coefficient values of WB-DWI and clinical parameters in multiple myeloma |
title_fullStr | Correlations between apparent diffusion coefficient values of WB-DWI and clinical parameters in multiple myeloma |
title_full_unstemmed | Correlations between apparent diffusion coefficient values of WB-DWI and clinical parameters in multiple myeloma |
title_short | Correlations between apparent diffusion coefficient values of WB-DWI and clinical parameters in multiple myeloma |
title_sort | correlations between apparent diffusion coefficient values of wb-dwi and clinical parameters in multiple myeloma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186136/ https://www.ncbi.nlm.nih.gov/pubmed/34103001 http://dx.doi.org/10.1186/s12880-021-00631-2 |
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