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The deletion of glucagon-like peptide-1 receptors expressing neurons in the dorsomedial hypothalamic nucleus disrupts the diurnal feeding pattern and induces hyperphagia and obesity
BACKGROUND: Feeding rhythm disruption contributes to the development of obesity. The receptors of glucagon-like peptide-1 (GLP-1) are distributed in the wide regions of the brain. Among these regions, GLP-1 receptors (GLP-1R) are expressed in the dorsomedial hypothalamic nucleus (DMH) which are know...
Autores principales: | Maejima, Yuko, Yokota, Shoko, Shimizu, Masaru, Horita, Shoichiro, Kobayashi, Daisuke, Hazama, Akihiro, Shimomura, Kenju |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186199/ https://www.ncbi.nlm.nih.gov/pubmed/34098999 http://dx.doi.org/10.1186/s12986-021-00582-z |
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