Detection of Free Toxin B in the Stool of Asymptomatic Clostridioides difficile Carriers by the Cell Cytotoxicity Neutralization Assay

Cell cytotoxicity neutralization assay (CCNA) is considered to be a gold standard to diagnose Clostridioides difficile infections. We performed CCNA on 77 consecutive admission screening rectal swabs from asymptomatic toxigenic C. difficile carriers. Thirty-nine percent of specimens from asymptomati...

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Autores principales: Schweitzer, Lorne, Gervais, Phillippe, Paquet-Bolduc, Bianka, Loo, Vivian G, Longtin, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186239/
https://www.ncbi.nlm.nih.gov/pubmed/34113687
http://dx.doi.org/10.1093/ofid/ofab209
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author Schweitzer, Lorne
Gervais, Phillippe
Paquet-Bolduc, Bianka
Loo, Vivian G
Longtin, Yves
author_facet Schweitzer, Lorne
Gervais, Phillippe
Paquet-Bolduc, Bianka
Loo, Vivian G
Longtin, Yves
author_sort Schweitzer, Lorne
collection PubMed
description Cell cytotoxicity neutralization assay (CCNA) is considered to be a gold standard to diagnose Clostridioides difficile infections. We performed CCNA on 77 consecutive admission screening rectal swabs from asymptomatic toxigenic C. difficile carriers. Thirty-nine percent of specimens from asymptomatic carriers were positive. Thus, CCNA specificity may be lower than previously thought.
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spelling pubmed-81862392021-06-09 Detection of Free Toxin B in the Stool of Asymptomatic Clostridioides difficile Carriers by the Cell Cytotoxicity Neutralization Assay Schweitzer, Lorne Gervais, Phillippe Paquet-Bolduc, Bianka Loo, Vivian G Longtin, Yves Open Forum Infect Dis Brief Reports Cell cytotoxicity neutralization assay (CCNA) is considered to be a gold standard to diagnose Clostridioides difficile infections. We performed CCNA on 77 consecutive admission screening rectal swabs from asymptomatic toxigenic C. difficile carriers. Thirty-nine percent of specimens from asymptomatic carriers were positive. Thus, CCNA specificity may be lower than previously thought. Oxford University Press 2021-04-25 /pmc/articles/PMC8186239/ /pubmed/34113687 http://dx.doi.org/10.1093/ofid/ofab209 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Schweitzer, Lorne
Gervais, Phillippe
Paquet-Bolduc, Bianka
Loo, Vivian G
Longtin, Yves
Detection of Free Toxin B in the Stool of Asymptomatic Clostridioides difficile Carriers by the Cell Cytotoxicity Neutralization Assay
title Detection of Free Toxin B in the Stool of Asymptomatic Clostridioides difficile Carriers by the Cell Cytotoxicity Neutralization Assay
title_full Detection of Free Toxin B in the Stool of Asymptomatic Clostridioides difficile Carriers by the Cell Cytotoxicity Neutralization Assay
title_fullStr Detection of Free Toxin B in the Stool of Asymptomatic Clostridioides difficile Carriers by the Cell Cytotoxicity Neutralization Assay
title_full_unstemmed Detection of Free Toxin B in the Stool of Asymptomatic Clostridioides difficile Carriers by the Cell Cytotoxicity Neutralization Assay
title_short Detection of Free Toxin B in the Stool of Asymptomatic Clostridioides difficile Carriers by the Cell Cytotoxicity Neutralization Assay
title_sort detection of free toxin b in the stool of asymptomatic clostridioides difficile carriers by the cell cytotoxicity neutralization assay
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186239/
https://www.ncbi.nlm.nih.gov/pubmed/34113687
http://dx.doi.org/10.1093/ofid/ofab209
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