Cargando…

Time to the Peak, Shape of the Curve and Combination of These Glucose Response Characteristics During Oral Glucose Tolerance Test as Indicators of Early Beta-cell Dysfunction in Obese Adolescents

OBJECTIVE: Characteristics of the glucose response during oral glucose tolerance test (OGTT) may reflect differences in insulin secretion and action. The aim was to examine whether timing of the glucose peak, shape of the glucose curve and their combination could be indicators of beta-cell dysfuncti...

Descripción completa

Detalles Bibliográficos
Autores principales: La Grasta Sabolić, Lavinia, Šepec, Marija Požgaj, Cigrovski Berković, Maja, Stipančić, Gordana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186335/
https://www.ncbi.nlm.nih.gov/pubmed/33006553
http://dx.doi.org/10.4274/jcrpe.galenos.2020.2020.0142
_version_ 1783704934533824512
author La Grasta Sabolić, Lavinia
Šepec, Marija Požgaj
Cigrovski Berković, Maja
Stipančić, Gordana
author_facet La Grasta Sabolić, Lavinia
Šepec, Marija Požgaj
Cigrovski Berković, Maja
Stipančić, Gordana
author_sort La Grasta Sabolić, Lavinia
collection PubMed
description OBJECTIVE: Characteristics of the glucose response during oral glucose tolerance test (OGTT) may reflect differences in insulin secretion and action. The aim was to examine whether timing of the glucose peak, shape of the glucose curve and their combination could be indicators of beta-cell dysfunction in obese/severely obese adolescents with normal glucose tolerance (NGT). METHODS: Data from 246 obese/severely obese adolescents who completed OGTT were reviewed. Out of 184 adolescents with NGT, 174 could be further classified into groups based on timing of the glucose peak (early/30 minutes vs late/≥60 minutes) and shape of the glucose curve (monophasic vs biphasic). Groups were compared with respect to insulin sensitivity (whole body insulin sensitivity index - WBISI), early-phase insulin secretion (insulinogenic index - IGI) and beta-cell function relative to insulin sensitivity (oral disposition index - oDI). RESULTS: Late glucose peak (p=0.004) and monophasic glucose curve (p=0.001) were both associated with lower oDI after adjustment for age, sex, puberty stage and body mass index z-score. Among obese/severely obese adolescents with NGT, those with coexistent late glucose peak and monophasic glucose curve had lower oDI than those with early glucose peak and biphasic glucose curve (p=0.002). Moreover, a combination of late glucose peak and monophasic glucose curve was the most powerful predictor of the lowest oDI quartile [odds ratio (OR): 11.68, 95% confidence interval: 3.048-44.755, p<0.001]. CONCLUSION: Late timing of the glucose peak, monophasic shape of the glucose curve and, in particular, a combination of those characteristics during OGTT may indicate early beta-cell dysfunction in obese/severely obese adolescents with NGT.
format Online
Article
Text
id pubmed-8186335
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Galenos Publishing
record_format MEDLINE/PubMed
spelling pubmed-81863352021-06-17 Time to the Peak, Shape of the Curve and Combination of These Glucose Response Characteristics During Oral Glucose Tolerance Test as Indicators of Early Beta-cell Dysfunction in Obese Adolescents La Grasta Sabolić, Lavinia Šepec, Marija Požgaj Cigrovski Berković, Maja Stipančić, Gordana J Clin Res Pediatr Endocrinol Original Article OBJECTIVE: Characteristics of the glucose response during oral glucose tolerance test (OGTT) may reflect differences in insulin secretion and action. The aim was to examine whether timing of the glucose peak, shape of the glucose curve and their combination could be indicators of beta-cell dysfunction in obese/severely obese adolescents with normal glucose tolerance (NGT). METHODS: Data from 246 obese/severely obese adolescents who completed OGTT were reviewed. Out of 184 adolescents with NGT, 174 could be further classified into groups based on timing of the glucose peak (early/30 minutes vs late/≥60 minutes) and shape of the glucose curve (monophasic vs biphasic). Groups were compared with respect to insulin sensitivity (whole body insulin sensitivity index - WBISI), early-phase insulin secretion (insulinogenic index - IGI) and beta-cell function relative to insulin sensitivity (oral disposition index - oDI). RESULTS: Late glucose peak (p=0.004) and monophasic glucose curve (p=0.001) were both associated with lower oDI after adjustment for age, sex, puberty stage and body mass index z-score. Among obese/severely obese adolescents with NGT, those with coexistent late glucose peak and monophasic glucose curve had lower oDI than those with early glucose peak and biphasic glucose curve (p=0.002). Moreover, a combination of late glucose peak and monophasic glucose curve was the most powerful predictor of the lowest oDI quartile [odds ratio (OR): 11.68, 95% confidence interval: 3.048-44.755, p<0.001]. CONCLUSION: Late timing of the glucose peak, monophasic shape of the glucose curve and, in particular, a combination of those characteristics during OGTT may indicate early beta-cell dysfunction in obese/severely obese adolescents with NGT. Galenos Publishing 2021-06 2021-06-02 /pmc/articles/PMC8186335/ /pubmed/33006553 http://dx.doi.org/10.4274/jcrpe.galenos.2020.2020.0142 Text en ©Copyright 2021 by Turkish Pediatric Endocrinology and Diabetes Society | The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
La Grasta Sabolić, Lavinia
Šepec, Marija Požgaj
Cigrovski Berković, Maja
Stipančić, Gordana
Time to the Peak, Shape of the Curve and Combination of These Glucose Response Characteristics During Oral Glucose Tolerance Test as Indicators of Early Beta-cell Dysfunction in Obese Adolescents
title Time to the Peak, Shape of the Curve and Combination of These Glucose Response Characteristics During Oral Glucose Tolerance Test as Indicators of Early Beta-cell Dysfunction in Obese Adolescents
title_full Time to the Peak, Shape of the Curve and Combination of These Glucose Response Characteristics During Oral Glucose Tolerance Test as Indicators of Early Beta-cell Dysfunction in Obese Adolescents
title_fullStr Time to the Peak, Shape of the Curve and Combination of These Glucose Response Characteristics During Oral Glucose Tolerance Test as Indicators of Early Beta-cell Dysfunction in Obese Adolescents
title_full_unstemmed Time to the Peak, Shape of the Curve and Combination of These Glucose Response Characteristics During Oral Glucose Tolerance Test as Indicators of Early Beta-cell Dysfunction in Obese Adolescents
title_short Time to the Peak, Shape of the Curve and Combination of These Glucose Response Characteristics During Oral Glucose Tolerance Test as Indicators of Early Beta-cell Dysfunction in Obese Adolescents
title_sort time to the peak, shape of the curve and combination of these glucose response characteristics during oral glucose tolerance test as indicators of early beta-cell dysfunction in obese adolescents
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186335/
https://www.ncbi.nlm.nih.gov/pubmed/33006553
http://dx.doi.org/10.4274/jcrpe.galenos.2020.2020.0142
work_keys_str_mv AT lagrastasaboliclavinia timetothepeakshapeofthecurveandcombinationoftheseglucoseresponsecharacteristicsduringoralglucosetolerancetestasindicatorsofearlybetacelldysfunctioninobeseadolescents
AT sepecmarijapozgaj timetothepeakshapeofthecurveandcombinationoftheseglucoseresponsecharacteristicsduringoralglucosetolerancetestasindicatorsofearlybetacelldysfunctioninobeseadolescents
AT cigrovskiberkovicmaja timetothepeakshapeofthecurveandcombinationoftheseglucoseresponsecharacteristicsduringoralglucosetolerancetestasindicatorsofearlybetacelldysfunctioninobeseadolescents
AT stipancicgordana timetothepeakshapeofthecurveandcombinationoftheseglucoseresponsecharacteristicsduringoralglucosetolerancetestasindicatorsofearlybetacelldysfunctioninobeseadolescents