COVID-19 leukoencephalopathy with subacute magnetic resonance imaging findings of vasculitis and demyelination

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) commonly results in a respiratory illness in symptomatic patients; however, those critically ill can develop a leukoencephalopathy. We describe two patients who had novel subacute MRI findings in the context of coronavirus disease 2019 (CO...

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Autores principales: Vahedi, Ali, Apap Mangion, Sean, Silber, Eli, Sibtain, Naomi, Chandra, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186364/
https://www.ncbi.nlm.nih.gov/pubmed/34101087
http://dx.doi.org/10.1007/s13365-021-00990-0
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author Vahedi, Ali
Apap Mangion, Sean
Silber, Eli
Sibtain, Naomi
Chandra, Julie
author_facet Vahedi, Ali
Apap Mangion, Sean
Silber, Eli
Sibtain, Naomi
Chandra, Julie
author_sort Vahedi, Ali
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) commonly results in a respiratory illness in symptomatic patients; however, those critically ill can develop a leukoencephalopathy. We describe two patients who had novel subacute MRI findings in the context of coronavirus disease 2019 (COVID-19) leukoencephalopathy, which we hypothesize could implicate a potent small-vessel vasculitis, ischemic demyelination and the presence of prolonged ischemia. Recent evidence of the direct neuroinvasiness of SARS-CoV-2 leading to ischemia and vascular damage supports this hypothesis.
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spelling pubmed-81863642021-06-09 COVID-19 leukoencephalopathy with subacute magnetic resonance imaging findings of vasculitis and demyelination Vahedi, Ali Apap Mangion, Sean Silber, Eli Sibtain, Naomi Chandra, Julie J Neurovirol Case Report Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) commonly results in a respiratory illness in symptomatic patients; however, those critically ill can develop a leukoencephalopathy. We describe two patients who had novel subacute MRI findings in the context of coronavirus disease 2019 (COVID-19) leukoencephalopathy, which we hypothesize could implicate a potent small-vessel vasculitis, ischemic demyelination and the presence of prolonged ischemia. Recent evidence of the direct neuroinvasiness of SARS-CoV-2 leading to ischemia and vascular damage supports this hypothesis. Springer International Publishing 2021-06-08 2021 /pmc/articles/PMC8186364/ /pubmed/34101087 http://dx.doi.org/10.1007/s13365-021-00990-0 Text en © Journal of NeuroVirology, Inc. 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Case Report
Vahedi, Ali
Apap Mangion, Sean
Silber, Eli
Sibtain, Naomi
Chandra, Julie
COVID-19 leukoencephalopathy with subacute magnetic resonance imaging findings of vasculitis and demyelination
title COVID-19 leukoencephalopathy with subacute magnetic resonance imaging findings of vasculitis and demyelination
title_full COVID-19 leukoencephalopathy with subacute magnetic resonance imaging findings of vasculitis and demyelination
title_fullStr COVID-19 leukoencephalopathy with subacute magnetic resonance imaging findings of vasculitis and demyelination
title_full_unstemmed COVID-19 leukoencephalopathy with subacute magnetic resonance imaging findings of vasculitis and demyelination
title_short COVID-19 leukoencephalopathy with subacute magnetic resonance imaging findings of vasculitis and demyelination
title_sort covid-19 leukoencephalopathy with subacute magnetic resonance imaging findings of vasculitis and demyelination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186364/
https://www.ncbi.nlm.nih.gov/pubmed/34101087
http://dx.doi.org/10.1007/s13365-021-00990-0
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