Vitamin D3 attenuates doxorubicin-induced senescence of human aortic endothelial cells by upregulation of IL-10 via the pAMPKα/Sirt1/Foxo3a signaling pathway

The toxicity of doxorubicin to the cardiovascular system often limits its benefits and widespread use as chemotherapy. The mechanisms involved in doxorubicin-induced cardiovascular damage and possible protective interventions are not well-explored. Using human aortic endothelial cells, we show vitam...

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Detalles Bibliográficos
Autores principales: Chen, Lei, Holder, Rachel, Porter, Charles, Shah, Zubair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186764/
https://www.ncbi.nlm.nih.gov/pubmed/34101754
http://dx.doi.org/10.1371/journal.pone.0252816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186764/
https://www.ncbi.nlm.nih.gov/pubmed/34101754
http://dx.doi.org/10.1371/journal.pone.0252816

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