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Can molecular dynamics simulations improve the structural accuracy and virtual screening performance of GPCR models?
The determination of G protein-coupled receptor (GPCR) structures at atomic resolution has improved understanding of cellular signaling and will accelerate the development of new drug candidates. However, experimental structures still remain unavailable for a majority of the GPCR family. GPCR struct...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186765/ https://www.ncbi.nlm.nih.gov/pubmed/33983933 http://dx.doi.org/10.1371/journal.pcbi.1008936 |