Laboratory diagnosis of human T-lymphotropic virus in Brazil: assays, flowcharts, challenges, and perspectives

INTRODUCTION: We present a data analysis and review of recent studies regarding the laboratory diagnosis of human T-lymphotropic virus 1 and 2 (HTLV-1/2) infections in Brazil. METHODS: Target populations, available diagnostic serological assays (screening and complementary tests), molecular assays (...

Descripción completa

Detalles Bibliográficos
Autores principales: Caterino-de-Araujo, Adele, Barbosa-Stancioli, Edel Figueiredo, Alonso, José Boullosa, Aragón, Mayra Gonçalves, Galvão-Castro, Bernardo, Ishak, Ricardo, Rosadas, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186893/
https://www.ncbi.nlm.nih.gov/pubmed/34105630
http://dx.doi.org/10.1590/0037-8682-0175-2021
Descripción
Sumario:INTRODUCTION: We present a data analysis and review of recent studies regarding the laboratory diagnosis of human T-lymphotropic virus 1 and 2 (HTLV-1/2) infections in Brazil. METHODS: Target populations, available diagnostic serological assays (screening and complementary tests), molecular assays (in-house), causes of false-positive and false-negative results, and flowcharts were analyzed. RESULTS: A table presents the target populations, two diagnostic flowcharts (depending on laboratory infrastructure and study population), and recent research that may improve how HTLV-1/2 is diagnosed in Brazil. CONCLUSIONS: Our results support the implementation of public policies to reduce HTLV-1/2 transmission and its associated diseases.

Ejemplares similares