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The organizational principles of de-differentiated topographic maps in somatosensory cortex
Topographic maps are a fundamental feature of cortex architecture in the mammalian brain. One common theory is that the de-differentiation of topographic maps links to impairments in everyday behavior due to less precise functional map readouts. Here, we tested this theory by characterizing de-diffe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186903/ https://www.ncbi.nlm.nih.gov/pubmed/34003108 http://dx.doi.org/10.7554/eLife.60090 |
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author | Liu, Peng Chrysidou, Anastasia Doehler, Juliane Hebart, Martin N Wolbers, Thomas Kuehn, Esther |
author_facet | Liu, Peng Chrysidou, Anastasia Doehler, Juliane Hebart, Martin N Wolbers, Thomas Kuehn, Esther |
author_sort | Liu, Peng |
collection | PubMed |
description | Topographic maps are a fundamental feature of cortex architecture in the mammalian brain. One common theory is that the de-differentiation of topographic maps links to impairments in everyday behavior due to less precise functional map readouts. Here, we tested this theory by characterizing de-differentiated topographic maps in primary somatosensory cortex (SI) of younger and older adults by means of ultra-high resolution functional magnetic resonance imaging together with perceptual finger individuation and hand motor performance. Older adults’ SI maps showed similar amplitude and size to younger adults’ maps, but presented with less representational similarity between distant fingers. Larger population receptive field sizes in older adults’ maps did not correlate with behavior, whereas reduced cortical distances between D2 and D3 related to worse finger individuation but better motor performance. Our data uncover the drawbacks of a simple de-differentiation model of topographic map function, and motivate the introduction of feature-based models of cortical reorganization. |
format | Online Article Text |
id | pubmed-8186903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-81869032021-06-09 The organizational principles of de-differentiated topographic maps in somatosensory cortex Liu, Peng Chrysidou, Anastasia Doehler, Juliane Hebart, Martin N Wolbers, Thomas Kuehn, Esther eLife Neuroscience Topographic maps are a fundamental feature of cortex architecture in the mammalian brain. One common theory is that the de-differentiation of topographic maps links to impairments in everyday behavior due to less precise functional map readouts. Here, we tested this theory by characterizing de-differentiated topographic maps in primary somatosensory cortex (SI) of younger and older adults by means of ultra-high resolution functional magnetic resonance imaging together with perceptual finger individuation and hand motor performance. Older adults’ SI maps showed similar amplitude and size to younger adults’ maps, but presented with less representational similarity between distant fingers. Larger population receptive field sizes in older adults’ maps did not correlate with behavior, whereas reduced cortical distances between D2 and D3 related to worse finger individuation but better motor performance. Our data uncover the drawbacks of a simple de-differentiation model of topographic map function, and motivate the introduction of feature-based models of cortical reorganization. eLife Sciences Publications, Ltd 2021-05-18 /pmc/articles/PMC8186903/ /pubmed/34003108 http://dx.doi.org/10.7554/eLife.60090 Text en © 2021, Liu et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Liu, Peng Chrysidou, Anastasia Doehler, Juliane Hebart, Martin N Wolbers, Thomas Kuehn, Esther The organizational principles of de-differentiated topographic maps in somatosensory cortex |
title | The organizational principles of de-differentiated topographic maps in somatosensory cortex |
title_full | The organizational principles of de-differentiated topographic maps in somatosensory cortex |
title_fullStr | The organizational principles of de-differentiated topographic maps in somatosensory cortex |
title_full_unstemmed | The organizational principles of de-differentiated topographic maps in somatosensory cortex |
title_short | The organizational principles of de-differentiated topographic maps in somatosensory cortex |
title_sort | organizational principles of de-differentiated topographic maps in somatosensory cortex |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186903/ https://www.ncbi.nlm.nih.gov/pubmed/34003108 http://dx.doi.org/10.7554/eLife.60090 |
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