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The organizational principles of de-differentiated topographic maps in somatosensory cortex

Topographic maps are a fundamental feature of cortex architecture in the mammalian brain. One common theory is that the de-differentiation of topographic maps links to impairments in everyday behavior due to less precise functional map readouts. Here, we tested this theory by characterizing de-diffe...

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Autores principales: Liu, Peng, Chrysidou, Anastasia, Doehler, Juliane, Hebart, Martin N, Wolbers, Thomas, Kuehn, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186903/
https://www.ncbi.nlm.nih.gov/pubmed/34003108
http://dx.doi.org/10.7554/eLife.60090
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author Liu, Peng
Chrysidou, Anastasia
Doehler, Juliane
Hebart, Martin N
Wolbers, Thomas
Kuehn, Esther
author_facet Liu, Peng
Chrysidou, Anastasia
Doehler, Juliane
Hebart, Martin N
Wolbers, Thomas
Kuehn, Esther
author_sort Liu, Peng
collection PubMed
description Topographic maps are a fundamental feature of cortex architecture in the mammalian brain. One common theory is that the de-differentiation of topographic maps links to impairments in everyday behavior due to less precise functional map readouts. Here, we tested this theory by characterizing de-differentiated topographic maps in primary somatosensory cortex (SI) of younger and older adults by means of ultra-high resolution functional magnetic resonance imaging together with perceptual finger individuation and hand motor performance. Older adults’ SI maps showed similar amplitude and size to younger adults’ maps, but presented with less representational similarity between distant fingers. Larger population receptive field sizes in older adults’ maps did not correlate with behavior, whereas reduced cortical distances between D2 and D3 related to worse finger individuation but better motor performance. Our data uncover the drawbacks of a simple de-differentiation model of topographic map function, and motivate the introduction of feature-based models of cortical reorganization.
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spelling pubmed-81869032021-06-09 The organizational principles of de-differentiated topographic maps in somatosensory cortex Liu, Peng Chrysidou, Anastasia Doehler, Juliane Hebart, Martin N Wolbers, Thomas Kuehn, Esther eLife Neuroscience Topographic maps are a fundamental feature of cortex architecture in the mammalian brain. One common theory is that the de-differentiation of topographic maps links to impairments in everyday behavior due to less precise functional map readouts. Here, we tested this theory by characterizing de-differentiated topographic maps in primary somatosensory cortex (SI) of younger and older adults by means of ultra-high resolution functional magnetic resonance imaging together with perceptual finger individuation and hand motor performance. Older adults’ SI maps showed similar amplitude and size to younger adults’ maps, but presented with less representational similarity between distant fingers. Larger population receptive field sizes in older adults’ maps did not correlate with behavior, whereas reduced cortical distances between D2 and D3 related to worse finger individuation but better motor performance. Our data uncover the drawbacks of a simple de-differentiation model of topographic map function, and motivate the introduction of feature-based models of cortical reorganization. eLife Sciences Publications, Ltd 2021-05-18 /pmc/articles/PMC8186903/ /pubmed/34003108 http://dx.doi.org/10.7554/eLife.60090 Text en © 2021, Liu et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Liu, Peng
Chrysidou, Anastasia
Doehler, Juliane
Hebart, Martin N
Wolbers, Thomas
Kuehn, Esther
The organizational principles of de-differentiated topographic maps in somatosensory cortex
title The organizational principles of de-differentiated topographic maps in somatosensory cortex
title_full The organizational principles of de-differentiated topographic maps in somatosensory cortex
title_fullStr The organizational principles of de-differentiated topographic maps in somatosensory cortex
title_full_unstemmed The organizational principles of de-differentiated topographic maps in somatosensory cortex
title_short The organizational principles of de-differentiated topographic maps in somatosensory cortex
title_sort organizational principles of de-differentiated topographic maps in somatosensory cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186903/
https://www.ncbi.nlm.nih.gov/pubmed/34003108
http://dx.doi.org/10.7554/eLife.60090
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