Prognostic Alternative Splicing Signatures in Esophageal Carcinoma

Alternative splicing (AS) is a method of increasing the number of proteins that the genome is capable of coding for, by altering the pre-mRNA during its maturation. This process provides the ability of a broad range of proteins to arise from a single gene. AS events are known to occur in up to 94% o...

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Autores principales: Dlamini, Zodwa, Hull, Rodney, Mbatha, Sikhumbuzo Z, Alaouna, Mohammed, Qiao, You-Lin, Yu, Herbert, Chatziioannou, Aristotelis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186946/
https://www.ncbi.nlm.nih.gov/pubmed/34113176
http://dx.doi.org/10.2147/CMAR.S305464
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author Dlamini, Zodwa
Hull, Rodney
Mbatha, Sikhumbuzo Z
Alaouna, Mohammed
Qiao, You-Lin
Yu, Herbert
Chatziioannou, Aristotelis
author_facet Dlamini, Zodwa
Hull, Rodney
Mbatha, Sikhumbuzo Z
Alaouna, Mohammed
Qiao, You-Lin
Yu, Herbert
Chatziioannou, Aristotelis
author_sort Dlamini, Zodwa
collection PubMed
description Alternative splicing (AS) is a method of increasing the number of proteins that the genome is capable of coding for, by altering the pre-mRNA during its maturation. This process provides the ability of a broad range of proteins to arise from a single gene. AS events are known to occur in up to 94% of human genes. Cumulative data have shown that aberrant AS functionality is a major factor in human diseases. This review focuses on the contribution made by aberrant AS functionality in the development and progression of esophageal cancer. The changes in the pattern of expression of alternately spliced isoforms in esophageal cancer can be used as diagnostic or prognostic biomarkers. Additionally, these can be used as targets for the development of new treatments for esophageal cancer.
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spelling pubmed-81869462021-06-09 Prognostic Alternative Splicing Signatures in Esophageal Carcinoma Dlamini, Zodwa Hull, Rodney Mbatha, Sikhumbuzo Z Alaouna, Mohammed Qiao, You-Lin Yu, Herbert Chatziioannou, Aristotelis Cancer Manag Res Review Alternative splicing (AS) is a method of increasing the number of proteins that the genome is capable of coding for, by altering the pre-mRNA during its maturation. This process provides the ability of a broad range of proteins to arise from a single gene. AS events are known to occur in up to 94% of human genes. Cumulative data have shown that aberrant AS functionality is a major factor in human diseases. This review focuses on the contribution made by aberrant AS functionality in the development and progression of esophageal cancer. The changes in the pattern of expression of alternately spliced isoforms in esophageal cancer can be used as diagnostic or prognostic biomarkers. Additionally, these can be used as targets for the development of new treatments for esophageal cancer. Dove 2021-06-04 /pmc/articles/PMC8186946/ /pubmed/34113176 http://dx.doi.org/10.2147/CMAR.S305464 Text en © 2021 Dlamini et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Dlamini, Zodwa
Hull, Rodney
Mbatha, Sikhumbuzo Z
Alaouna, Mohammed
Qiao, You-Lin
Yu, Herbert
Chatziioannou, Aristotelis
Prognostic Alternative Splicing Signatures in Esophageal Carcinoma
title Prognostic Alternative Splicing Signatures in Esophageal Carcinoma
title_full Prognostic Alternative Splicing Signatures in Esophageal Carcinoma
title_fullStr Prognostic Alternative Splicing Signatures in Esophageal Carcinoma
title_full_unstemmed Prognostic Alternative Splicing Signatures in Esophageal Carcinoma
title_short Prognostic Alternative Splicing Signatures in Esophageal Carcinoma
title_sort prognostic alternative splicing signatures in esophageal carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186946/
https://www.ncbi.nlm.nih.gov/pubmed/34113176
http://dx.doi.org/10.2147/CMAR.S305464
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