Can We AlphaFold Our Way Out of the Next Pandemic?

The announcement of the outstanding performance of AlphaFold 2 in the CASP 14 protein structure prediction competition came at the end of a long year defined by the COVID-19 pandemic. With an infectious organism dominating the world stage, the developers of Alphafold 2 were keen to play their part,...

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Detalles Bibliográficos
Autor principal: Higgins, Matthew K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186955/
https://www.ncbi.nlm.nih.gov/pubmed/34116123
http://dx.doi.org/10.1016/j.jmb.2021.167093
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author Higgins, Matthew K.
author_facet Higgins, Matthew K.
author_sort Higgins, Matthew K.
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description The announcement of the outstanding performance of AlphaFold 2 in the CASP 14 protein structure prediction competition came at the end of a long year defined by the COVID-19 pandemic. With an infectious organism dominating the world stage, the developers of Alphafold 2 were keen to play their part, accurately predicting novel structures of two proteins from SARS-CoV-2. In their blog post of December 2020, they highlighted this contribution, writing “we’ve also seen signs that protein structure prediction could be useful in future pandemic response efforts”. So, what role does structural biology play in guiding vaccine immunogen design and what might be the contribution of AlphaFold 2?
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spelling pubmed-81869552021-06-09 Can We AlphaFold Our Way Out of the Next Pandemic? Higgins, Matthew K. J Mol Biol Review Article The announcement of the outstanding performance of AlphaFold 2 in the CASP 14 protein structure prediction competition came at the end of a long year defined by the COVID-19 pandemic. With an infectious organism dominating the world stage, the developers of Alphafold 2 were keen to play their part, accurately predicting novel structures of two proteins from SARS-CoV-2. In their blog post of December 2020, they highlighted this contribution, writing “we’ve also seen signs that protein structure prediction could be useful in future pandemic response efforts”. So, what role does structural biology play in guiding vaccine immunogen design and what might be the contribution of AlphaFold 2? Elsevier Ltd. 2021-10-01 2021-06-08 /pmc/articles/PMC8186955/ /pubmed/34116123 http://dx.doi.org/10.1016/j.jmb.2021.167093 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Higgins, Matthew K.
Can We AlphaFold Our Way Out of the Next Pandemic?
title Can We AlphaFold Our Way Out of the Next Pandemic?
title_full Can We AlphaFold Our Way Out of the Next Pandemic?
title_fullStr Can We AlphaFold Our Way Out of the Next Pandemic?
title_full_unstemmed Can We AlphaFold Our Way Out of the Next Pandemic?
title_short Can We AlphaFold Our Way Out of the Next Pandemic?
title_sort can we alphafold our way out of the next pandemic?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186955/
https://www.ncbi.nlm.nih.gov/pubmed/34116123
http://dx.doi.org/10.1016/j.jmb.2021.167093
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